Table 4 Main functions of upregulated miRNAs predicted by bioinformatic analysis
miRNA | Putative target genes | KEGG pathway | Genes involved in the term | % of involved genes/total genes | p-value |
|---|---|---|---|---|---|
(Homo sapiens) | |||||
miR-1181 | 2 | - | - | - | - |
miR-125a-5p | 162 | Pathways in cancer | 8 | 4.9 | 3.60E-02 |
| Â | Â | Cell cycle | 4 | 2.5 | 1.20E-01 |
miR-21-3p | 210 | Cell adhesion molecules | 7 | 3.3 | 4.70E-03 |
| Â | Â | Ubiquitin mediated proteolysis | 6 | 2.9 | 2.30E-02 |
| Â | Â | Oocyte meiosis | 5 | 2.4 | 4.20E-02 |
miR-29b-1-5p | 265 | Insulin signaling pathway | 5 | 1.9 | 8.50E-02 |
| Â | Â | Cell cycle | 4 | 1.5 | 2.00E-01 |
| Â | Â | Wnt signaling pathway | 4 | 1.5 | 2.90E-01 |
| Â | Â | Jak-STAT signaling pathway | 4 | 1.5 | 3.00E-01 |
miR-3663-3p | 305 | MAPK signaling pathway | 12 | 3.9 | 5.90E-03 |
| Â | Â | Pathways in cancer | 11 | 3.6 | 5.50E-02 |
| Â | Â | Focal adhesion | 7 | 2.3 | 1.30E-01 |
| Â | Â | Cytokine-cytokine receptor interaction | 7 | 2.3 | 3.00E-01 |
miR-371a-5p | 351 | Spliceosome | 8 | 2.3 | 4.20E-03 |
| Â | Â | Wnt signaling pathway | 7 | 2 | 3.60E-02 |
miR-4327 | 112 | MAPK signaling pathway | 4 | 3.6 | 1.20E-01 |
| Â | Â | Pathways in cancer | 4 | 3.6 | 1.80E-01 |
| Â | Â | Melanoma | 3 | 2.7 | 4.00E-02 |
| Â | Â | Calcium signaling pathway | 3 | 2.7 | 1.90E-01 |
miR-584-5p | 288 | MAPK signaling pathway | 8 | 2.8 | 9.70E-02 |
| Â | Â | Pathways in cancer | 8 | 2.8 | 2.10E-01 |
miR-602 | 302 | MAPK signaling pathway | 7 | 2.3 | 2.20E-01 |
| Â | Â | Insulin signaling pathway | 6 | 2 | 5.30E-02 |
|  |  | Alzheimer’s disease | 6 | 2 | 1.00E-01 |
| Â | Â | Calcium signaling pathway | 6 | 2 | 1.30E-01 |
miR-629-3p | 445 | Pathways in cancer | 10 | 2.3 | 2.10E-01 |
miR-642b-3p | 262 | Glioma | 4 | 1.5 | 3.20E-02 |
| Â | Â | Melanoma | 4 | 1.5 | 4.30E-02 |
| Â | Â | Cell adhesion molecules | 5 | 1.8 | 5.70E-02 |
miR-651 | 60 | Calcium signaling pathway | 3 | 4.3 | 5.40E-01 |
| Â | Â | Ubiquitin mediated proteolysis | 3 | 4.3 | 6.00E-02 |
| Â | Â | Regulation of autophagy | 2 | 2.9 | 9.90E-02 |
miR-762 | 534 | Axon guidance | 16 | 3 | 6.60E-07 |
| Â | Â | MAPK signaling pathway | 16 | 3 | 2.90E-03 |
| Â | Â | Wnt signaling pathway | 13 | 2.4 | 4.00E-04 |
miR-874 | 176 | B and T cell receptor signaling pathway | 4 | 2.3 | 2.20E-02 |
| Â | Â | MAPK signaling pathway | 4 | 2.3 | 3.70E-01 |
mir-890 | 325 | Wnt signaling pathway | 7 | 2.1 | 6.50E-02 |
| Â | Â | ErbB signaling pathway | 5 | 1.5 | 8.10E-02 |
miR-939 | 365 | Calcium signaling pathway | 10 | 2.4 | 1.30E-02 |
| Â | Â | ErbB signaling pathway | 5 | 1.2 | 1.20E-01 |
| Â | Â | p53 signaling pathway | 4 | 0.9 | 1.80E-01 |
| Â | Â | Wnt signaling pathway | 6 | 1.4 | 2.20E-01 |