Skip to main content

Table 4 Main functions of upregulated miRNAs predicted by bioinformatic analysis

From: Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells

miRNA Putative target genes KEGG pathway Genes involved in the term % of involved genes/total genes p-value
(Homo sapiens)
miR-1181 2 - - - -
miR-125a-5p 162 Pathways in cancer 8 4.9 3.60E-02
   Cell cycle 4 2.5 1.20E-01
miR-21-3p 210 Cell adhesion molecules 7 3.3 4.70E-03
   Ubiquitin mediated proteolysis 6 2.9 2.30E-02
   Oocyte meiosis 5 2.4 4.20E-02
miR-29b-1-5p 265 Insulin signaling pathway 5 1.9 8.50E-02
   Cell cycle 4 1.5 2.00E-01
   Wnt signaling pathway 4 1.5 2.90E-01
   Jak-STAT signaling pathway 4 1.5 3.00E-01
miR-3663-3p 305 MAPK signaling pathway 12 3.9 5.90E-03
   Pathways in cancer 11 3.6 5.50E-02
   Focal adhesion 7 2.3 1.30E-01
   Cytokine-cytokine receptor interaction 7 2.3 3.00E-01
miR-371a-5p 351 Spliceosome 8 2.3 4.20E-03
   Wnt signaling pathway 7 2 3.60E-02
miR-4327 112 MAPK signaling pathway 4 3.6 1.20E-01
   Pathways in cancer 4 3.6 1.80E-01
   Melanoma 3 2.7 4.00E-02
   Calcium signaling pathway 3 2.7 1.90E-01
miR-584-5p 288 MAPK signaling pathway 8 2.8 9.70E-02
   Pathways in cancer 8 2.8 2.10E-01
miR-602 302 MAPK signaling pathway 7 2.3 2.20E-01
   Insulin signaling pathway 6 2 5.30E-02
   Alzheimer’s disease 6 2 1.00E-01
   Calcium signaling pathway 6 2 1.30E-01
miR-629-3p 445 Pathways in cancer 10 2.3 2.10E-01
miR-642b-3p 262 Glioma 4 1.5 3.20E-02
   Melanoma 4 1.5 4.30E-02
   Cell adhesion molecules 5 1.8 5.70E-02
miR-651 60 Calcium signaling pathway 3 4.3 5.40E-01
   Ubiquitin mediated proteolysis 3 4.3 6.00E-02
   Regulation of autophagy 2 2.9 9.90E-02
miR-762 534 Axon guidance 16 3 6.60E-07
   MAPK signaling pathway 16 3 2.90E-03
   Wnt signaling pathway 13 2.4 4.00E-04
miR-874 176 B and T cell receptor signaling pathway 4 2.3 2.20E-02
   MAPK signaling pathway 4 2.3 3.70E-01
mir-890 325 Wnt signaling pathway 7 2.1 6.50E-02
   ErbB signaling pathway 5 1.5 8.10E-02
miR-939 365 Calcium signaling pathway 10 2.4 1.30E-02
   ErbB signaling pathway 5 1.2 1.20E-01
   p53 signaling pathway 4 0.9 1.80E-01
   Wnt signaling pathway 6 1.4 2.20E-01