Figure 5

Effects of EAAS on IL-1β-induced MAPK signal pathways and NF-kB activation in RASFs. IL-1β enhanced the phosphorylation of ERK, p38, and JNK and EAAS inhibited the IL-1β-induced activation of p38 and JNK (a). IL-1β activated nuclear NF-kB and decreased cytoplasmic IkBα and EAAS inhibited the IL-1β-induced activation of NF-kB (b). Results are presented as mean ± SD. n = 3. *p < 0.01 versus no IL-1β and EAAS, ‡p < 0.05 versus IL-1β without EAAS.