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Table 6 SNP haplotype frequencies in the Madeira reference set and the asthmatics study population

From: Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

Haplotype block   Study sample set
   Madeira reference set Overall asthma Intermittent asthma Persistent asthma Mild Moderate-severe
  105a 98 24 74 44 30
IL4-590/ IL4-RP2 T183 0.088 0.168 (0.019) 0.125 0.182 (0.011) 0.125 0.267 (3x10 -4 /0.029*)
  C253 0.894 0.806 0.833 0.797 0.852 0.717 (0.004/0.044*)
IL4-590 /ADRB2-c.16 TA 0.018 0.058 (0.037) 0.064 0.055 (0.048) 0.031 0.085 (0.009)
  TG 0.092 0.136 0.102 0.148 0.117 0.199 (0.023)
IL4-RP2/ADRB2-c.16 183A 0.025 0.057 0.059 0.056 0.032 0.089 (0.026)
  183G 0.084 0.111 0.066 0.127 0.093 0.178 (0.037)
IL13-c.144/ IL4-590 GT 0.064 0.134 (0.018) 0.098 0.146 (0.010) 0.128 0.166 (0.010)
  AT 0.046 0.060 0.068 0.057 0.020 0.110 (0.020*)
IL13-c.144/ IL4-RP2 G183 0.059 0.106 0.052 0.124 (0.033) 0.105 0.147 (0.022)
  A183 0.050 0.063 0.073 0.059 0.021 0.114 (0.017*)
IL13-c.144/ IL4-590/ IL4-RP2 GT183 0.051 0.107 (0.041) 0.054 0.125 (0.016) 0.105 0.148 (0.009)
  AT183 0.040 0.062 0.071 0.058 0.020 0.119 (0.024/0.018*)
IL4-590/ IL4-RP2/ ADRB2-c.16 T183A 0.016 0.055 (0.038) 0.052 0.053 (0.045) 0.030 0.082 (0.008)
  T183G 0.073 0.113 0.067 0.129 0.095 0.184 (0.013)
  1. Haplotypes denoting significant differences are shown in bold, with respective p-values within parentheses. Significant p-values, using Madeira reference set as a control, are shown within parentheses; * significant p-values for comparison between mild persistent and moderate-severe persistent.
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