|
Haplotype block
| |
Study sample set
|
|---|
| | |
Madeira reference set
|
Overall asthma
|
Intermittent asthma
|
Persistent asthma
|
Mild
|
Moderate-severe
|
|---|
| |
105a
|
98
|
24
|
74
|
44
|
30
|
|
IL4-590/ IL4-RP2
|
T183
|
0.088
|
0.168 (0.019)
|
0.125
|
0.182 (0.011)
|
0.125
|
0.267 (3x10
-4
/0.029*)
|
| |
C253
|
0.894
|
0.806
|
0.833
|
0.797
|
0.852
|
0.717 (0.004/0.044*)
|
|
IL4-590 /ADRB2-c.16
|
TA
|
0.018
|
0.058 (0.037)
|
0.064
|
0.055 (0.048)
|
0.031
|
0.085 (0.009)
|
| |
TG
|
0.092
|
0.136
|
0.102
|
0.148
|
0.117
|
0.199 (0.023)
|
|
IL4-RP2/ADRB2-c.16
|
183A
|
0.025
|
0.057
|
0.059
|
0.056
|
0.032
|
0.089 (0.026)
|
| |
183G
|
0.084
|
0.111
|
0.066
|
0.127
|
0.093
|
0.178 (0.037)
|
|
IL13-c.144/ IL4-590
|
GT
|
0.064
|
0.134 (0.018)
|
0.098
|
0.146 (0.010)
|
0.128
|
0.166 (0.010)
|
| |
AT
|
0.046
|
0.060
|
0.068
|
0.057
|
0.020
|
0.110 (0.020*)
|
|
IL13-c.144/ IL4-RP2
|
G183
|
0.059
|
0.106
|
0.052
|
0.124 (0.033)
|
0.105
|
0.147 (0.022)
|
| |
A183
|
0.050
|
0.063
|
0.073
|
0.059
|
0.021
|
0.114 (0.017*)
|
|
IL13-c.144/ IL4-590/ IL4-RP2
|
GT183
|
0.051
|
0.107 (0.041)
|
0.054
|
0.125 (0.016)
|
0.105
|
0.148 (0.009)
|
| |
AT183
|
0.040
|
0.062
|
0.071
|
0.058
|
0.020
|
0.119 (0.024/0.018*)
|
|
IL4-590/ IL4-RP2/ ADRB2-c.16
|
T183A
|
0.016
|
0.055 (0.038)
|
0.052
|
0.053 (0.045)
|
0.030
|
0.082 (0.008)
|
| |
T183G
|
0.073
|
0.113
|
0.067
|
0.129
|
0.095
|
0.184 (0.013)
|
- Haplotypes denoting significant differences are shown in bold, with respective p-values within parentheses. Significant p-values, using Madeira reference set as a control, are shown within parentheses; * significant p-values for comparison between mild persistent and moderate-severe persistent.
