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Table 6 SNP haplotype frequencies in the Madeira reference set and the asthmatics study population

From: Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

Haplotype block

 

Study sample set

  

Madeira reference set

Overall asthma

Intermittent asthma

Persistent asthma

Mild

Moderate-severe

 

105a

98

24

74

44

30

IL4-590/ IL4-RP2

T183

0.088

0.168 (0.019)

0.125

0.182 (0.011)

0.125

0.267 (3x10 -4 /0.029*)

 

C253

0.894

0.806

0.833

0.797

0.852

0.717 (0.004/0.044*)

IL4-590 /ADRB2-c.16

TA

0.018

0.058 (0.037)

0.064

0.055 (0.048)

0.031

0.085 (0.009)

 

TG

0.092

0.136

0.102

0.148

0.117

0.199 (0.023)

IL4-RP2/ADRB2-c.16

183A

0.025

0.057

0.059

0.056

0.032

0.089 (0.026)

 

183G

0.084

0.111

0.066

0.127

0.093

0.178 (0.037)

IL13-c.144/ IL4-590

GT

0.064

0.134 (0.018)

0.098

0.146 (0.010)

0.128

0.166 (0.010)

 

AT

0.046

0.060

0.068

0.057

0.020

0.110 (0.020*)

IL13-c.144/ IL4-RP2

G183

0.059

0.106

0.052

0.124 (0.033)

0.105

0.147 (0.022)

 

A183

0.050

0.063

0.073

0.059

0.021

0.114 (0.017*)

IL13-c.144/ IL4-590/ IL4-RP2

GT183

0.051

0.107 (0.041)

0.054

0.125 (0.016)

0.105

0.148 (0.009)

 

AT183

0.040

0.062

0.071

0.058

0.020

0.119 (0.024/0.018*)

IL4-590/ IL4-RP2/ ADRB2-c.16

T183A

0.016

0.055 (0.038)

0.052

0.053 (0.045)

0.030

0.082 (0.008)

 

T183G

0.073

0.113

0.067

0.129

0.095

0.184 (0.013)

  1. Haplotypes denoting significant differences are shown in bold, with respective p-values within parentheses. Significant p-values, using Madeira reference set as a control, are shown within parentheses; * significant p-values for comparison between mild persistent and moderate-severe persistent.
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Biological Research

ISSN: 0717-6287

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