Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

Biological Research

Table 5 Skin prick tests positivity across SNP genotypes

Allergen panel			SNP genotypes
			ADAM33-V4 C/G
		n	GG	CG	CC	p-value	OR (95% CI)
Dermatophagoides pteronyssinus	(-)	23	0.043	0.348	0.609
Dermatophagoides pteronyssinus	(+)	74	0	0.203	0.797
	< 10 mm	44	0	0.295	0.705
	≥ 10 mm	30	0	0.067	0.933	0.016	1.325 (1.070-1.641)
Blomia tropicalis	(-)	43	0.023	0.279	0.698
	(+)	54	0	0.204	0.796
	< 10 mm	42	0	0.262	0.738
	≥ 10 mm	12	0	0	1.00	0.047	1.355 (1.131-1.622)
			STAT6-21 C/T
			CC	CT	TT
Storage mites	(-)	53	0.396	0.472	0.132
	(+)	44	0.500	0.364	0.236
	< 10 mm	35	0.514	0.429	0.057
	≥ 10 mm	9	0.444	0.111	0.444	0.003*	7.778 (1.682-35.962)

Only significant associations are reported, in bold.
Storage mites: Lepidoglyphus destructor, Glycifagus domesticus, Acarus siro, Euroglyphus maynei and Tyrophagus putrescentiae allergens, classified as ≥ 10 mm if at least one test resulted in wheal diameter ≥ 10 mm.*Recessive model.

ISSN: 0717-6287