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Citation: Biological Research 2023 56:39
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Beyond energy provider: multifunction of lipid droplets in embryonic development
Since the discovery, lipid droplets (LDs) have been recognized to be sites of cellular energy reserves, providing energy when necessary to sustain cellular life activities. Many studies have reported large num...
Citation: Biological Research 2023 56:38 -
Retraction Note: Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
Citation: Biological Research 2023 56:37 -
Electroacupuncture protective effects after cerebral ischemia are mediated through miR-219a inhibition
Electroacupuncture (EA) is a complementary and alternative therapy which has shown protective effects on vascular cognitive impairment (VCI). However, the underlying mechanisms are not entirely understood.
Citation: Biological Research 2023 56:36 -
Topsoil and subsoil bacterial community assemblies across different drainage conditions in a mountain environment
High mountainous environments are of particular interest as they play an essential role for life and human societies, while being environments which are highly vulnerable to climate change and land use intensi...
Citation: Biological Research 2023 56:35 -
Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2-mutation associated with dilated cardiomyopathy and left ventricular non-compaction
Dilated cardiomyopathy (DCM) is a primary myocardial disease, leading to heart failure and excessive risk of sudden cardiac death with rather poorly understood pathophysiology. In 2015, Parvari's group ident...
Citation: Biological Research 2023 56:34 -
Human VDAC pseudogenes: an emerging role for VDAC1P8 pseudogene in acute myeloid leukemia
Voltage-dependent anion selective channels (VDACs) are the most abundant mitochondrial outer membrane proteins, encoded in mammals by three genes, VDAC1, 2 and 3, mostly ubiquitously expressed. As 'mitochondrial ...
Citation: Biological Research 2023 56:33 -
ABCA1 transporter promotes the motility of human melanoma cells by modulating their plasma membrane organization
Melanoma is one of the most aggressive and deadliest skin tumor. Cholesterol content in melanoma cells is elevated, and a portion of it accumulates into lipid rafts. Therefore, the plasma membrane cholesterol ...
Citation: Biological Research 2023 56:32 -
Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p
The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells. Acupuncture has been sho...
Citation: Biological Research 2023 56:31 -
Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells
Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besi...
Citation: Biological Research 2023 56:30 -
iPSCs ameliorate hypoxia-induced autophagy and atrophy in C2C12 myotubes via the AMPK/ULK1 pathway
Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for which there is no effective treatment. Previous studies have shown that stem cell transplantation into mdx mice can promote muscle r...
Citation: Biological Research 2023 56:29 -
Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux
Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and de...
Citation: Biological Research 2023 56:28 -
Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson’s disease models
The underlying mechanism of Parkinson’s disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are trans...
Citation: Biological Research 2023 56:27 -
Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL
Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic...
Citation: Biological Research 2023 56:26 -
Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors
Mechanoreceptor activation modulates GABA neuron firing and dopamine (DA) release in the mesolimbic DA system, an area implicated in reward and substance abuse. The lateral habenula (LHb), the lateral hypothal...
Citation: Biological Research 2023 56:25 -
Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
Citation: Biological Research 2023 56:24 -
Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditions
Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare inherited skin disease caused by variants in the COL7A1 gene, coding for type VII collagen (C7), an important component of anchoring fibrils in the base...
Citation: Biological Research 2023 56:23 -
Conformational characterization of the mammalian-expressed SARS-CoV-2 recombinant receptor binding domain, a COVID-19 vaccine
The COVID-19 pandemic has caused a large number of diseases worldwide. There are few vaccines to constrain this disease and the value of them is high. In this sense, the antigens of the vaccine platform Sobera...
Citation: Biological Research 2023 56:22 -
NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration
Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanism...
Citation: Biological Research 2023 56:21 -
Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling
Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-ind...
Citation: Biological Research 2023 56:20 -
Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction
AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle pr...
Citation: Biological Research 2023 56:19 -
In situ isolation of nuclei or nuclear proteins from adherent cells: a simple, effective method with less cytoplasmic contamination
Isolation of nuclei or nuclear proteins is a prerequisite for western blot, nuclear proteome profiling, and other evaluations of nuclear proteins. Here, we developed a simple method for in situ isolation of nu...
Citation: Biological Research 2023 56:18 -
Spontaneous spheroids from alveolar bone-derived mesenchymal stromal cells maintain pluripotency of stem cells by regulating hypoxia-inducible factors
Spontaneous spheroid culture is a novel three-dimensional (3D) culture strategy for the rapid and efficient selection of progenitor cells. The objectives of this study are to investigate the pluripotency and d...
Citation: Biological Research 2023 56:17 -
Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model
Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-rel...
Citation: Biological Research 2023 56:16 -
Spleen regeneration after subcutaneous heterotopic autotransplantation in a mouse model
Splenectomy may lead to severe postoperative complications, including sepsis and cancers. A possible solution to this problem is heterotopic autotransplantation of the spleen. Splenic autografts rapidly restor...
Citation: Biological Research 2023 56:15 -
The CB1 cannabinoid receptor regulates autophagy in the tibialis anterior skeletal muscle in mice
The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 cannabinoid receptor (CB1). Likewise...
Citation: Biological Research 2023 56:14 -
Retraction Note: Salinity-induced changes in the morphology and major mineral nutrient composition of purslane (Portulaca oleracea L.) accessions
Citation: Biological Research 2023 56:13 -
The pattern of alternative splicing and DNA methylation alteration and their interaction in linseed (Linum usitatissimum L.) response to repeated drought stresses
Drought stress has significantly hampered agricultural productivity worldwide and can also result in modifications to DNA methylation levels. However, the dynamics of DNA methylation and its association with t...
Citation: Biological Research 2023 56:12 -
Prospective insight into the role of benzyl propylene glycoside as a modulator of the cGAS-STING signaling pathway in the management of nonalcoholic fatty pancreas animal model
Nonalcoholic fatty pancreatitis (NAFP) is one of the metabolic syndrome manifestations that need further studies to determine its molecular determinants and find effective medications. We aimed to investigate ...
Citation: Biological Research 2023 56:11 -
DYRK1-mediated phosphorylation of endocytic components is required for extracellular lumen expansion in ascidian notochord
The biological tube is a basal biology structure distributed in all multicellular animals, from worms to humans, and has diverse biological functions. Formation of tubular system is crucial for embryogenesis a...
Citation: Biological Research 2023 56:10 -
DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation
Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the relationship between genomic regions subject to DNA-m...
Citation: Biological Research 2023 56:9 -
Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated in...
Citation: Biological Research 2023 56:8 -
YULINK regulates vascular formation in zebrafish and HUVECs
The distinct arterial and venous cell fates are dictated by a combination of various genetic factors which form diverse types of blood vessels such as arteries, veins, and capillaries. We report here that YULI...
Citation: Biological Research 2023 56:7 -
DNA sequencing in the classroom: complete genome sequence of two earwig (Dermaptera; Insecta) species
Despite representing the largest fraction of animal life, the number of insect species whose genome has been sequenced is barely in the hundreds. The order Dermaptera (the earwigs) suffers from a lack of genom...
Citation: Biological Research 2023 56:6 -
Alpha‐kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway
Alpha‐kinase 1 (ALPK1) is a master regulator in inflammation and has been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic nephropathy (DN) mice. Pyroptosis is involved in high...
Citation: Biological Research 2023 56:5 -
Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation
Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be disc...
Citation: Biological Research 2023 56:4 -
Synergistic effects of dendrosomal nanocurcumin and oxaliplatin on oncogenic properties of ovarian cancer cell lines by down-expression of MMPs
Contrary to the advantageous anticancer activities of curcumin (Cur), limited bioavailability and solubility hindered its efficacy. Here, nontoxic dendrosomal nano carrier with Cur was used to overcome these p...
Citation: Biological Research 2023 56:3 -
Cisplatin-induced azoospermia and testicular damage ameliorated by adipose-derived mesenchymal stem cells
The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages of life. Exposure to these threats mainly occurs during cancer treatment and as an occupational hazard in ra...
Citation: Biological Research 2023 56:2 -
Cell cycle related long non-coding RNAs as the critical regulators of breast cancer progression and metastasis
Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, ...
Citation: Biological Research 2023 56:1 -
Sperm DNA integrity does play a crucial role for embryo development after ICSI, notably when good-quality oocytes from young donors are used
Based on the inconsistent literature published thus far involving infertile patients, whether intracytoplasmic sperm injection (ICSI) allows overcoming total fertilization failure due to sperm DNA fragmentatio...
Citation: Biological Research 2022 55:41 -
Auricular cartilage regeneration using different types of mesenchymal stem cells in rabbits
Cartilaginous disorders comprise a wide range of diseases that affect normal joint movement, ear and nose shape; and they have great social and economic impact. Mesenchymal stem cells (MSCs) provide a promisin...
Citation: Biological Research 2022 55:40 -
Inflammation context in Alzheimer’s disease, a relationship intricate to define
Alzheimer’s disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates. Importantly, Aβ and tau species are able to ac...
Citation: Biological Research 2022 55:39 -
Protocol paper: kainic acid excitotoxicity-induced spinal cord injury paraplegia in Sprague–Dawley rats
Excitotoxicity-induced in vivo injury models are vital to reflect the pathophysiological features of acute spinal cord injury (SCI) in humans. The duration and concentration of chemical treatment controls the ...
Citation: Biological Research 2022 55:38 -
Dynamic circadian fluctuations of glycemia in patients with type 2 diabetes mellitus
Diabetes mellitus (DM) has glucose variability that is of such relevance that the appearance of vascular complications in patients with DM has been attributed to hyperglycemic and dysglycemic events. It is kno...
Citation: Biological Research 2022 55:37 -
Correction: Acupuncture attenuates comorbid anxiety- and depressive-like behaviors of atopic dermatitis through modulating neuroadaptation in the brain reward circuit in mice
Citation: Biological Research 2022 55:36 -
Extracellular signals regulate the biogenesis of extracellular vesicles
Extracellular vesicles (EVs) are naturally released membrane vesicles that act as carriers of proteins and RNAs for intercellular communication. With various biomolecules and specific ligands, EV has represent...
Citation: Biological Research 2022 55:35 -
Oocyte quality assessment in marine invertebrates: a novel approach by fluorescence spectroscopy
The assessment of oocyte quality is, nowadays, a major challenge in aquaculture, oocyte cryopreservation, and environmental science. Oocyte quality is a determining factor in fertilization and embryo developme...
Citation: Biological Research 2022 55:34 -
Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties
Ionizing radiations (IR) have widespread useful applications in our daily life; however, they have unfavorable effects on reproductive health. Maintaining testicular health following IR exposure is an importan...
Citation: Biological Research 2022 55:33 -
The production of the first functional antibody mimetic in higher plants: the chloroplast makes the DARPin G3 for HER2 imaging in oncology
Designed mimetic molecules are attractive tools in biopharmaceuticals and synthetic biology. They require mass and functional production for the assessment of upcoming challenges in the near future. The DARPin...
Citation: Biological Research 2022 55:32 -
Genetically modified organisms: adapting regulatory frameworks for evolving genome editing technologies
Genetic modification of living organisms has been a prosperous activity for research and development of agricultural, industrial and biomedical applications. Three decades have passed since the first genetical...
Citation: Biological Research 2022 55:31
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- ISSN: 0717-6287 (electronic)