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  1. Research article

    Morphological, molecular and FTIR spectroscopic analysis during the differentiation of kidney cells from pluripotent stem cells

    Kidney diseases are a global health problem. Currently, over 2 million people require dialysis or transplant which are associated with high morbidity and mortality; therefore, new researches focused on regener...

    Monica Maribel Mata-Miranda, Gustavo Jesus Vazquez-Zapien, Marlon Rojas-Lopez, Virginia Sanchez-Monroy, David Guillermo Perez-Ishiwara and Raul Jacobo Delgado-Macuil

    Biological Research 2017 50:14

    Published on: 4 April 2017

  2. Research article

    Musk gland seasonal development and musk secretion are regulated by the testis in muskrat (Ondatra zibethicus)

    The muskrat is a seasonal breeder. Males secrete musk to attract females during the breeding season. The testosterone binding to the androgen receptor (AR) in musk glands of muskrat may play an important role ...

    Tianxiang Zhang, Dong Peng, Lei Qi, Weixuan Li, Mengyuan Fan, Jiachen Shen, Liangliang Yang, Yihua Wang, Wenxia Wang, Xiaolong Hu, Ruibo Cai, Ran Zhou, Yuting Wei, Juntong Zhou, Shuang Yang, Defu Hu…

    Biological Research 2017 50:10

    Published on: 4 March 2017

  3. Research article

    BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis

    CD4+ T cells play an important role in the initiation of an immune response by providing help to other cells. Among the helper T subsets, interferon-γ (IFN-γ)-secreting T helper 1 (Th1) and IL-17-secreting T help...

    Youra Kang, Maheshwor Timilshina, Tae-gyu Nam, Byeong-Seon Jeong and Jae-Hoon Chang

    Biological Research 2017 50:8

    Published on: 28 February 2017

  4. Short report

    De novo transcriptome assembly, functional annotation and differential gene expression analysis of juvenile and adult E. fetida, a model oligochaete used in ecotoxicological studies

    Earthworms are sensitive to toxic chemicals present in the soil and so are useful indicator organisms for soil health. Eisenia fetida are commonly used in ecotoxicological studies; therefore the assembly of a bas...

    Michelle Thunders, Jo Cavanagh and Yinsheng Li

    Biological Research 2017 50:7

    Published on: 27 February 2017

  5. Short report

    Differential roles for pathogenicity islands SPI-13 and SPI-8 in the interaction of Salmonella Enteritidis and Salmonella Typhi with murine and human macrophages

    Salmonella pathogenicity island (SPI)-13 is conserved in many serovars of S. enterica, including S. Enteritidis, S. Typhimurium and S. Gallinarum. However, it is absent in typhoid sero...

    Rodrigo A. Espinoza, Cecilia A. Silva-Valenzuela, Fernando A. Amaya, Ítalo M. Urrutia, Inés Contreras and Carlos A. Santiviago

    Biological Research 2017 50:5

    Published on: 15 February 2017

  6. Research article

    Metabotropic glutamate receptor 5 may be involved in macrophage plasticity

    Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulat...

    Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze and David Mikeladze

    Biological Research 2017 50:4

    Published on: 14 February 2017

    The Erratum to this article has been published in Biological Research 2017 50:13

  7. Research article

    Uptake of DNA by cancer cells without a transfection reagent

    Cancer cells exhibit elevated levels of glucose uptake and may obtain pre-formed, diet-derived fatty acids from the bloodstream to boost their rapid growth; they may also use nucleic acid from their microenvir...

    Yanping Kong, Xianbo Zhang, Yongliang Zhao, Yanfang Xue and Ye Zhang

    Biological Research 2017 50:2

    Published on: 21 January 2017

  8. Short report

    A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells

    Pathologic vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury promotes the development of occlusive vascular disease. Therefore, an effective chemical agent to suppress aberra...

    Hyang-Hee Seo, Sang Woo Kim, Chang Youn Lee, Kyu Hee Lim, Jiyun Lee, Eunhyun Choi, Soyeon Lim, Seahyoung Lee and Ki-Chul Hwang

    Biological Research 2017 50:1

    Published on: 18 January 2017

  9. Research article

    Klotho sensitive regulation of dendritic cell functions by vitamin E

    Dendritic cells (DCs) are the most potent professional antigen-presenting cells for naive T cells to link innate and acquired immunity. Klotho, an anti-aging protein, participates in the regulation of Ca2+ depend...

    Nguyen Thi Xuan, Phi Thi Thu Trang, Nguyen Van Phong, Nguyen Linh Toan, Do Minh Trung, Nguyen Duy Bac, Viet Linh Nguyen, Nguyen Huy Hoang and Nong Van Hai

    Biological Research 2016 49:45

    Published on: 24 November 2016

  10. Research article

    Olfactomedin-like 2 A and B (OLFML2A and OLFML2B) expression profile in primates (human and baboon)

    The olfactomedin-like domain (OLFML) is present in at least four families of proteins, including OLFML2A and OLFML2B, which are expressed in adult rat retina cells. However, no expression of their orthologous ...

    Diana Cristina Pérez-Ibave, Rafael González-Alvarez, Margarita de La Luz Martinez-Fierro, Gabriel Ruiz-Ayma, Maricela Luna-Muñoz, Laura Elia Martínez-De-Villarreal, María De Lourdes Garza-Rodríguez, Diana Reséndez-Pérez, Jibran Mohamed-Noriega, Raquel Garza-Guajardo, Víctor Manuel Bautista-De-Lucío, Karim Mohamed-Noriega, Oralia Barboza-Quintana, Carlos Arámburo-De-La-Hoz, Hugo Alberto Barrera-Saldaña and Irám Pablo Rodríguez-Sánchez

    Biological Research 2016 49:44

    Published on: 8 November 2016

  11. Research article

    Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis

    Heavy metals can cause great harm to Siberian tigers in the natural environment. Cadmium (Cd2+) is an environmental contaminant that affects multiple cellular processes, including cell proliferation, differentiat...

    Hui Wang, Zheng Liu, Wenxiu Zhang, Ziao Yuan, Hongyi Yuan, Xueting Liu, Chunwen Yang and Weijun Guan

    Biological Research 2016 49:42

    Published on: 24 October 2016

  12. Research article

    Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model

    Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflam...

    Hwan-Hee Jang, Su-Yeon Cho, Mi-Ju Kim, Jung-Bong Kim, Sung-Hyen Lee, Mee-Young Lee and Young-Min Lee

    Biological Research 2016 49:41

    Published on: 5 October 2016

  13. Research article

    Improved assembly procedure of viral RNA genomes amplified with Phi29 polymerase from new generation sequencing data

    New sequencing technologies have opened the way to the discovery and the characterization of pathogenic viruses in clinical samples. However, the use of these new methods can require an amplification of viral ...

    Nicolas Berthet, Stéphane Descorps-Declère, Andriniaina Andy Nkili-Meyong, Emmanuel Nakouné, Antoine Gessain, Jean-Claude Manuguerra and Mirdad Kazanji

    Biological Research 2016 49:39

    Published on: 7 September 2016

  14. Research article

    Potential role of marine algae extract on 3T3-L1 cell proliferation and differentiation: an in vitro approach

    From ancient times, marine algae have emerged as alternative medicine and foods, contains the rich source of natural products like proteins, vitamins, and secondary metabolites, especially Chlorella vulgaris (C. ...

    Soundharrajan Ilavenil, Da Hye Kim, Mayakrishnan Vijayakumar, Srisesharam Srigopalram, Sang Gun Roh, Mariadhas Valan Arasu, Jong Suk Lee and Ki Choon Choi

    Biological Research 2016 49:38

    Published on: 7 September 2016

  15. Research article

    Growth hormone in the presence of laminin modulates interaction of human thymic epithelial cells and thymocytes in vitro

    Several evidences indicate that hormones and neuropeptides function as immunomodulators. Among these, growth hormone (GH) is known to act on the thymic microenvironment, supporting its role in thymocyte differ...

    Marvin Paulo Lins, Larissa Fernanda de Araújo Vieira, Alfredo Aurélio Marinho Rosa and Salete Smaniotto

    Biological Research 2016 49:37

    Published on: 2 September 2016

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