Noncoding RNAs in skeletal development and disorders

Biological Research

Table 2 The role of some ncRNAs in osteoporosis and their mechanisms through bone absorption validated in the transgenic mice model

ncRNA type	ncRNA name	Target genes and pathways	Transgenic mice	Function	Ref
miRNA	miR-21	Spry1 and PDCD4	miR-21-/-	miR-21 deficiency inhibited bone resorption and osteoclast function	[173]
miRNA	miR-128	SIRT1/NF-κB signaling	miR-128 fl/fl; LysM-Cre	Osteoclastic deletion of miR-128 suppressed osteoclastogenesis and exerted a protective effect against bone loss	[174]
miRNA	miR-143/145	Cd226 and Srgap2	miR-143/145-/-	miR-143/145 were shuttled into osteoclasts in extracellular vesicles and triggered osteoclastic activity	[169]
miRNA	miR-146a	RANKL/OPG signaling	miR-146a-/-	OC activities were impaired in the miR-146a KO mice exposed to estrogen deficiency	[123]
miRNA	miR-148a	NRP1	miR-148a-/-	miR-148a KO protects mice against excessive bone resorption	[175]
miRNA	miR-301b	CYLD/NF-κB signaling	miR-301-bfl/fl; LysM-Cre	Osteoclastic miR-301-b ablation inhibited OVX-induced osteoclastogenesis	[176]
lncRNA	Nron	CUL4B/Erα signaling	Nronfl/fl; Ctsk-Cre	Nron knockout mice exhibit an osteopenia phenotype with elevated bone resorption activity	[177]

ISSN: 0717-6287