Table 1 Summary of the promotion of EMT by Gal-2, Gal-3, Gal-4, and Gal-7 in tissue repair

Gal-2 and Gal- 4

Intestinal epithelium cells

Exogenously added, blockade with lactose

Increased wound closure and proliferation

TGF-β

[103]

Gal-3

Cornea cells from mice

Deletion in mice, exogenously added, blockade with lactose

Increased wound closure

N.D

[105]

Colon epithelium cells

Exogenously added, blockade with lactose

Increased wound closure

N.D

[113]

Mice epidermis and cells

Deletion in mice

Increased cell migration

EGFR/ERK

[108]

Immortalized keratinocytes and keratinocytes isolated from patients

Exogenously added, blockade with lactose

Weakening of cell-cell adhesion and increased cell migration

β4 integrin/laminin332/EGFR

[111]

Human corneal keratinocytes and mice

Deletion in mice, exogenously added, blockade with lactose

Occludin mislocalization, weakening of cell-cell adhesion, reorganization of the actin cytoskeleton, MMP-9 secretion, and cell detachment

CD147

[112]

Gal-7

Mice

Deletion in mice

E-cadherin/ β -catenin mislocalization, increased proliferation, decreased cell migration

N.D

[116]

Mice and keratinocyte cell lines

Overexpression in mice epidermis

Decreased E-cadherin, weakening of cell-cell adhesion

N.D

[117]

Epidermal cells

Knockdown, exogenously added, blockade with lactose

Cell polarity, wound closure, E-cadherin on cell surface

N.D

[118]