Fig. 12From: YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditionsScheme of the molecular mechanisms underlying YME1L regulates the senescent phenotype and mitophagy of RTECs. The downregulation of YME1L expression under HG ambiance disrupts mitophagy by reducing the phosphorylation of BCL2L13 and the combination between BCL2L13 and LC3, which in turn exacerbate cellular senescence of RTECsBack to article page