Table 1 Antimicrobial susceptibility profile and detection of carbapenemase genes and its expression in K. pneumoniae VA585-22 and E. coli K12 transconjugants that acquired pVA585-22_54
VA585-22 | K12(GenR) | K12-1 | K12-2 | |
|---|---|---|---|---|
Antibiotic class Antibiotic | MIC (µg/mL) | MIC (µg/mL) | MIC (µg/mL) | MIC (µg/mL) |
AminopenicillinAmpicillin | > 16R | 8S | > 16R | > 16R |
Ampicillin/Sulbactam | > 16/8R | ≤ 4/2S | > 16/8R | > 16/8R |
Piperacillin/Tazobactam | > 32/4R | ≤ 4/4S | > 64/4R | > 64/4R |
Cephalosporin 1st Cephazolin | > 16R | ≤ 2S | > 16R | > 16R |
Cephalosporin 2nd Cefoxitin Ceftriaxone Cephalosporin 3rd Ceftazidime | > 16R > 4R > 16R | ≤ 4S ≤ 0.5S ≤ 0.5S | > 16R > 4R > 16R | > 16R > 4R > 16R |
Ceftazidime/Avibactam Cephalosporin 4th Cefepime | > 16/4R > 16R | ≤ 0.25/4S 2S | > 16/4R > 16R | > 16/4R > 16R |
Cephalosporin 5th Ceftolozane/Tazobactam | > 32/4R | ≤ 1/4S | > 32/4R | > 32/4R |
MonobactamAztreonam Ertapenem CarbapenemMeropenem | 16R > 2R 8R | ≤ 1S ≤ 0.25S ≤ 0.5S | 16R 2R 2I | 16R 2R 4R |
Imipenem | 16R | 1S | 8R | 8R |
TetracyclineMinocycline | 2S | 4S | 2S | 2S |
GlicilcyclineTigecycline | ≤ 0.25NI | ≤ 1NI | ≤ 1NI | ≤ 1NI |
AminoglycosideAmikacin | 16R | 32R | > 32R | > 32R |
Gentamicin | ≤ 0.5S | 8R | > 8R | > 8R |
Fluoroquinolone 2nd Ciprofloxacin | ≤ 0.064S | ≤ 0.125S | ≤ 0.125S | ≤ 0.125S |
Norfloxacin Fluoroquinolone 3rd Levofloxacin | ≤ 2S ≤ 1I | ≤ 2S ≤ 1I | ≤ 2S ≤ 1I | ≤ 2S ≤ 1I |
Other Fosfomycin Colistin | ≤ 16S 0.5I | ≤ 16S ≤ 1I | ≤ 16S 0.5I | ≤ 16S 0.5I |
1Carbapenemase gene blaKPC | + | - | + | + |
blaVIM | + | - | + | + |
2Carbapenemase expression | ||||
VIM-1 | + | - | + | + |
KPC-2 | + | - | + | + |