Fig. 3

Schematic representation of the main resistance genes, virulence factors, and mobile genetic elements in the CR-hvKp strain K. pneumoniae VA585-22. The virulence and metal resistance factors encoded in GIE492 (mce, MccE492 and salmochelin), ICEKp10 (ybt, yersiniabactin; clb, colibactin), and pKPVP-1 (iuc, aerobactin; iro, salmochelin; fep, iron transporter; fec, Fur-dependent system for iron uptake) are colored in magenta. For simplicity, only one export and one import protein complexes are depicted. The virulence plasmid also includes the sil, pco, pbr, and ter genes linked with resistance to copper, silver, lead, and tellurite, respectively, and the rmp genes linked to capsule upregulation. The antibiotic resistance proteins encoded in pVA585-22_54 are presented in dark blue (VIM-1 and KPC-2 carbapenemases, DfrA1 trimethoprim-resistant dihydrofolate reductase, ANT(3’’)-Ia aminoglycoside nucleotidyltransferase, AAC(6’)-II aminoglycoside acetyltransferase, and Sul1 sulfonamide-resistant dihydropteroate synthase). Created with BioRender.com