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Fig. 7 | Biological Research

Fig. 7

From: Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression

Fig. 7

MT alleviates AS. (A) Representative images of en face samples stained with Oil Red O and in vivo photos of the aortas of ApoE−/− mice in the NCD, NCD + nicotine, NCD + nicotine + MT, HFD, HFD + nicotine, and HFD + nicotine + MT groups. (B) HE staining of aortic root sections shows atherosclerotic lesions. (C) Oil red O staining of aortic root sections shows lipid deposition. (D) Masson staining was used to determine the content of collagen fibers in the root of the aortic arch (Blue represents collagen fibers.). (E) The expression of ASC was detected by immunohistochemistry (Brown represents ASC.). n = 10 mice in each group. The scale bar is 600 μm. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. NCD. #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. HFD

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