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Table 4 Levels of TNF, IL-1, IL-6, IL-10 and TGFβ1 in lung

From: Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia

Group

Cytokine (pg/mL)

1.5h

Median (Min–Max)

6h

Median (Min–Max)

12h

Median (Min–Max)

Male

Female

Male

Female

Male

Female

Normal

TNF

IL-1

IL-6

IL-10

TGFβ

83 (15–1031)

296 (15–734)

232 (15–617)

194 (15–376)

737 (326–887)

163 (15–806)

439 (44–7086)

95 (15–1032)

256 (15–1092)

790 (466–888)

ExSh

TNF

IL-1

IL-6

IL-10

TGFβ

76 (64–185)

3299 (1147–3761)*

270 (75–438)

15 (15–210)

205 (151–510)

99 (15–134)

2671 (1540–4023)

494 (15–527)

224 (140–1088)

1291 (165–1505)

15 (15–43)

3855 (2521–5654)***

697 (606–940)

329 (104–355)

6327 (366–6763)

15 (15–58)*

1455 (561–3180)

740 (15–1198)

52 (15–61)

3623 (3254–4709)*

ND

1835 (15–4493)

153 (15–583)

160 (15–272)

59310 (13787–62049)*

56 (23–81)

1339 (267–1529)

170 (52–483)

157 (137–692)

28180 (15847–42366)*

CLP

TNF

IL-1

IL-6

IL-10

TGFβ

ND

215 (15–461)

ND

45 (15–165)

282 (187–1056)

15 (15–45)

48 (15–83)*

15 (15–236)

52 (15–80)

1291 (244–2362)

89 (15–157)

145 (127–4488)

52 (15–23157)

44 (15–168)

1165 (426–3782)

62 (15–147)

214 (126–1793)

131(15–636)

196 (112–326)

2794 (1501–4502)*

15 (15–102)

68 (39–229)

15 (15–273)

47 (15–141)

16094 (11479–16588)*

15 (15–22)*

61 (15–142)

ND

77 (51–152)

14017 (5000–16695)*

  1. TNF Tumoral Necrosis Factor, IL-1 Interleukin 1, IL-6 Interleukin 6, IL-10 Interleukin 10, TGFβ1 Transforming Growth Factor beta
  2. Statistical differences were considered when *p < 0.05, , ***p < 0.0005 vs Normal. N = 13 mice per N group, N = 4–5 mice per experimental group