Fig. 3

TGF detection by immunohistochemistry in the lungs of LPS- or CLP-treated mice. A Occasional alveolar macrophages and alveolar cells show TGF immunostaining in the lung of a control female mouse. B In contrast, numerous TGF-immunostained cells are present in the alveolar capillary interstitium of the lungs of female mice treated with LPS. C Numerous TGF-immunostained cells are also present in the lumen and alveolar capillary interstitium of the lungs of CLP-treated female mice. D The lungs of male mice do not show TGF-immunostained cells. E The alveolar space and walls of the lungs of male mice treated with LPS show some TGF-immunostained cells. F Similar TGF immunostaining pattern is seen in the lungs of mice after CLP procedure. (all photomicrographs × 400 magnification). This is a representative micrograph of three