Fig.  2

Inflammation of lung and liver from mice treated with LPS or CLP. A Lung section from male mice treated with LPS by the ip route, mildly sized patches of lung tissue whose alveolar lumen is occupied by acellular fibrillary acidophilic material (arrows) with few inflammatory cells. B Similar but fewer and smaller lesions are seen in a male mouse with CLP. C Liver section from male mice treated with LPS shows some portal areas with mild inflammatory infiltrate (arrow). D Similar lesions are seen in male mouse with CLP. E Compared with male mice, female mice treated with LPS show fewer and smaller areas of inflammatory infiltrate in the alveolar-capillary interstitium and scarce eosinophilic fibrillar material on the surface of the alveolar epithelium. F Similar lung lesions are seen in a female mouse with CLP. G Some portal areas show a scar-like inflammatory infiltrate in the liver of female mice treated with LPS. H Similar liver lesions are seen in female mouse with CLP (all sections were stained with hematoxylin and eosin, original magnification × 400). This is a representative photomicrograph of three