Fig. 7

The effect of treatment with zofenopril on the participation of Mas receptors in endothelium dependent vasorelaxation in thoracic aortas isolated from rats without (a) or with (b) MLN-4760. SHR – untreated spontaneously hypertensive rats (n = 10); SHR + MLN – spontaneously hypertensive rats treated by MLN-4760 (n = 9); SHR + ZOFE – spontaneously hypertensive rats treated by zofenopril (n = 8); SHR + MLN + ZOFE – spontaneously hypertensive rats treated by MLN-4760 and zofenopril (n = 8). +A799 – aortic rings incubated with A-799 trifluoroacetate salt. The results are presented as the mean ± S.E.M., and differences between groups were analyzed by three-way ANOVA, ^## p < 0.01, ^### p < 0.001 vs. the respective group without A799p, ^§§§ p < 0.001 vs. SHR + A799