Fig. 5
The effect of treatment with zofenopril on the participation of NO/NOS in endothelium dependent vasorelaxation in thoracic aortas isolated from rats without (a) or with (b) MLN-4760. SHR – untreated spontaneously hypertensive rats (n = 10); SHR + MLN – spontaneously hypertensive rats treated by MLN-4760 (n = 9); SHR + ZOFE – spontaneously hypertensive rats treated by zofenopril (n = 8); SHR + MLN + ZOFE – spontaneously hypertensive rats treated by MLN-4760 and zofenopril (n = 8). +L-NAME – aortic rings incubated with NG-nitro-L-arginine methylester. The results are presented as the mean ± S.E.M., and differences between groups were analyzed by three-way ANOVA, # p < 0.05, ### p < 0.001 vs. the respective group without L-NAME, §§§ p < 0.001 vs. SHR + L-NAME, >>> p < 0.001 vs. SHR + MLN + L-NAME