Fig. 2

The effect of MLN and ZOFE treatment on left ventricular ejection fraction (LVEF) (a), left ventricular fractional shortening (LVFS) (b), the ratio of the diastolic transmitral peak early and late filling velocities (E/A ratio) (c), and the ratio of the diastolic transmitral peak early filling velocity and the maximal velocity of early diastolic wall movement wave at the level of mitral annulus (E/Em ratio) (d). SHR – spontaneously hypertensive rats (n = 8), SHR + MLN – spontaneously hypertensive rats treated by MLN-4760 (n = 8), SHR + ZOFE – spontaneously hypertensive rats treated by zofenopril (n = 8), SHR + MLN + ZOFE – spontaneously hypertensive rats treated by MLN-4760 and zofenopril (n = 8). The results are presented as the mean ± S.E.M., and differences between groups were analyzed by two-way ANOVA, * p < 0.05 vs. SHR, ⁺ p < 0.05 vs. SHR + MLN