Fig. 12

The total NOS activity and superoxide production in left ventricle (a,c) and aortic tissue (b,d). SHR – spontaneously hypertensive rats (n = 8), SHR + MLN – spontaneously hypertensive rats treated by MLN-4760 (n = 8), SHR + ZOFE - spontaneously hypertensive rats treated by zofenopril (n = 8), SHR + MLN + ZOFE - spontaneously hypertensive rats simultaneously treated by MLN-4760 and zofenopril (n = 8). The results are presented as the mean ± S.E.M., and differences between groups were analyzed by two-way ANOVA, * p < 0.05, *** p < 0.001 vs. SHR, ⁺⁺⁺ p < 0.001 vs. SHR + MLN, ^§ p < 0.05 vs. SHR + ZOFE