Fig. 4

Boxplots of significantly differential metabolites and sample clustering by sparse partial-least-squares discriminant analysis of metabolite profiles detected in 3- and 7-day-induced anoikis-resistant or wild-type NCI-H460 cells. (A) The significantly differential metabolites were determined based on their normalized concentrations, where * = p < 0.01, ** = p < 0.005, and *** = p < 0.001. (B) This 3-dimensional clustering view represents the similarities and dissimilarities between eight metabolite profiles per each cell type