Fig. 7

EA regulated synaptic plasticity and neuronal activity in the EC-HIP CA1 circuit

(A) Schematic representation of electrical stimulation protocols that induce LTP at the EC-HIP CA1 circuit in 2-VO rats. (B) Normalized fEPSP slopes of HFS-induced LTP. (C) The percentage of fEPSP slope changes during 50–60 min following LTP induction in each group. (D) Representative sEPSC traces in the hippocampus from the experiments described. (E, F). Averaged sEPSC amplitudes and frequencies in hippocampus. G. Representative sEPSC traces from experiments described in the entorhinal cortex. (H, I) Averaged sEPSC amplitudes and frequencies in the entorhinal cortex. * VS Sham group, P<0.05, **, P<0.01. #,VS 2-VO group, P<0.05. ^, VS EA group, P<0.05. (C.E-F,H-I One-way ANOVA, followed by a Tukey’s post hoc test, n = 6 sections from 3 rats/group, Data represent the mean ± SD)