Human VDAC pseudogenes: an emerging role for VDAC1P8 pseudogene in acute myeloid leukemia

Biological Research

Table 2 List of transcription factors TFs for VDAC1P8 detected in blood and bone marrow

Class	Family	Subfamily	Name		Tissue		Role in leukemogenesis (Ref.)
Class	Family	Subfamily	Name		Bone marrow	Blood	Role in leukemogenesis (Ref.)
Basic helix-loop-helix factors bHLH)	bHLH-ZIP	AP-4	MYC	Myc/Max factors	✓	X	[35, 38]
Basic helix-loop-helix factors bHLH)	Tal-related	TAL-HEN	TAL1	Tal-related factors	X	✓	[38, 43]
Basic leucine zipper factors bZIP	Jun-related	Jun	JUND	JunD proto-oncogene			[54]
	B-ATF-related		BATF	B-ATF-related			[48]
	Fos-related	Fos	FOS	Fos proto-oncogene	✓	X	[45]
	CEBP-related	CEBP	CEBPB	CCAAT/enhancer binding protein beta
	CEBP-related	CEBP	CEBPD	CCAAT/enhancer binding protein delta
Other C4 zinc finger-type factors	GATA-related	GATA double	GATA1	GATA binding protein 1			[37, 45]
			GATA2	GATA binding protein 2	X	✓
			GATA3	GATA binding protein 3	X	✓
C2H2 zinc finger factors	More than 3 adjacent zinc fingers	CTCF-like	CTCF	CCCTC-binding factor	✓	X	[41, 42]
C2H2 zinc finger factors	More than 3 adjacent zinc fingers	ZNF362-like	ZNF384	Zinc Finger Protein 384	X	✓	[39]
Tryptophan cluster factors	Myb-SANT	NCoR-like	RCOR1	REST corepressor 1	✓	X	[47]
	ETS-related	SPI-like	SPI1	Spi-1 proto-oncogene	✓		[45, 46]
		ETS-like	ETS1	Ets-protoncogene 1	X	✓	[44]
			ERG	Ets-related factors			[36, 38]
			FLI1	Fli-1 protoncogene			[40]
			IRF4	Interferon-regulatory factors			[34]
Runt domain factors	Runt-related		RUNX1	Runt domain factors	✓		[37, 44, 45]

	Type	Name		Tissue		Role in leukemogenesis Refs
	Type	Name		Bone marrow	Blood	Role in leukemogenesis Refs
Other TFs	Epigenetic reader	BRD4	Bromodomain containing 4	✓		[38, 51]
	Heterochomatin protein 1 HP1 family	CBX3	Chromobox 3	✓	X	[50]
	Synthesizing messenger RNA	POLR2A	RNA polymerase II subunit A	✓		[52]
	CTCF-transcriptional coactivators	RAD21	RAD21 cohesin complex component	✓		[38]
	CTCF-transcriptional coactivators	STAG1	Stromal antigen 1	X	✓	[38]

In bold are the names of the transcription factors identified
The analysis was performed by querying the hTFtarget database http://bioinfo.life.hust.edu.cn/hTFtarget#!/ and selecting only candidate TFs found in blood and bone marrow

ISSN: 0717-6287