Fig. 1

Chromatin state and genomic features of VDAC1P8 pseudogene from UCSC Genome Browser GRCh37/hg19. The genomic context of VDAC1P8 pseudogene set around 1000 Kb upstream and downstream of the annotated Refseq is shown. The selected regulatory hub tracks are Pseudogene Annotation Set from GENCODE v.38lift37 Ensemble 104, Eukaryotic Promoter Database EPD v.4–6, CpG island track, Genotype-Tissue Expression GTEx RNA-seq v.8 2019, ChIP-Seq data for RNA polymerase II, H3K4me3 and H3K4me1, used as markers of transcriptional activation, while H3K9me3 and H3K27me3 are markers of transcriptional repression, and chromatin state segmentation by Hidden Markov Model from the ENCODE/Broad project of nine different cell lines (GM12878, H1-hESC, HepG2, HMEC, HUVEC, K562, NHEK, NHLF) identified using the following different colors: yellow = weak/poised enhancer; blue = isolator; dark green = transcriptional transition/elongation (Txn), light green = weak transcript