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Fig. 8 | Biological Research

Fig. 8

From: Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus

Fig. 8

Graphical representation of mTOR regulation by HBOT. Left panel: Control condition, characterized by normal oxygen concentration and basal proliferation of ISCs. Middle panel: HBOT condition, featuring increased oxygen concentration and enhanced mTORC1 activity, potentially mediated by Nrf2. Right panel: Combined HBOT and Rapamycin administration, exhibiting higher oxygen concentration (compared to control) but lacking enhanced mTORC1 activity due to opposing effects of rapamycin and HBOT on mTOR signaling. Brown cells depict epithelial cells, green cells represent non-proliferative intestinal stem cells, red cells represent proliferative intestinal stem cells, and red circles symbolize oxygen molecules

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Biological Research

ISSN: 0717-6287

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