Fig. 1

Initial screening of small molecules for VSMC proliferation suppression. A total of 43 small molecule inhibitors of various kinases with no reported anti-proliferative effect on VSMC were screened. Rat VSMCs were treated with 10 μM of each small molecule for 24 h, and the cellular proliferation was evaluated by cell counting kits (CCK-8). Un (vehicle): 10% FBS supplemented DMSO containing DMSO 2%, v/v, indicated as white box with oblique pattern. Blue arrow indicates the most effective small molecule. The quantitative data were expressed as the mean ± SEM of at least three independent experiments. Full names of each small molecule are listed in Table 1