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Table 1 Cytotoxicity (LC50 in µg/mL) and the selectivity index (SI) of three limonoids isolated from Trichilia welwitschii and reference compounds (doxorubicin and puromycin) against cancer cell lines

From: Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae)

Compounds

Vero

THP-1

RAW 264.7

LC50

SI

LC50

SI

1

89.17 ± 5.00a

81.20 ± 6.38a

0.87

23.55 ± 5.77a

2.99

2

85.22 ± 6.31a

81.20 ± 4.04a

0.87

65.68 ± 3.64b

1.07

3

75.82 ± 1.85b

84.53 ± 5.81a

0.83

61.86 ± 4.14b

1.14

Doxorubicin

9.35 ± 0.66c

nd

nd

1.06 ± 0.65c

66.42

Puromycin

5.32 ± 0.90d

0.4 ± 0.02b

176.03

1.15 ± 0.17c

61.23

  1. Values with different letters are significantly different at p < 0.05
  2. nd not determined