Table 5 Main functions of downregulated miRNAs predicted by bioinformatic analysis
miRNA | Putative target genes | KEGG pathway | Genes involved in the term | % of involved genes/total genes | p-value |
|---|---|---|---|---|---|
(Homo sapiens) | |||||
miR-1290 | 593 | Pathways in cancer | 17 | 2.9 | 4.00E-02 |
| Â | Â | Focal adhesion | 14 | 2.4 | 7.90E-03 |
| Â | Â | Insulin signaling pathway | 13 | 2.2 | 7.60E-04 |
| Â | Â | MAPK signaling pathway | 12 | 2 | 1.90E-01 |
| Â | Â | ErbB signaling pathway | 11 | 1.9 | 2.80E-04 |
miR-1915-3p | 351 | Wnt signaling pathway | 8 | 2.3 | 5.60E-03 |
| Â | Â | Pathways in cancer | 7 | 2 | 3.30E-01 |
miR-2861 | 170 | Fc gamma R-mediated phagocytosis | 4 | 2.2 | 3.60E-02 |
| Â | Â | MAPK signaling pathway | 6 | 3.4 | 5.10E-02 |
| Â | Â | Arachidonic acid metabolism | 3 | 1.7 | 6.80E-02 |
miR-3665 | 195 | Neurotrophin signaling pathway | 4 | 2.1 | 1.10E-01 |
| Â | Â | Insulin signaling pathway | 4 | 2.1 | 1.30E-01 |
| Â | Â | MAPK signaling pathway | 4 | 2.1 | 4.70E-01 |
miR-4257 | 197 | - | - | - | - |
miR-452-5p | 327 | Oocyte meiosis | 8 | 2.3 | 1.30E-03 |
| Â | Â | Wnt signaling pathway | 7 | 2 | 2.60E-02 |
| Â | Â | ECM-receptor interaction | 5 | 1.4 | 3.80E-02 |
miR-513a-5p | 980 | MAPK signaling pathway | 25 | 2.6 | 1.00E-02 |
| Â | Â | Pathways in cancer | 24 | 2.4 | 1.30E-01 |
| Â | Â | Regulation of actin cytoskeleton | 20 | 2 | 2.50E-02 |
miR-572 | 6 | - | - | - | - |
miR-629-3p | 445 | Pathways in cancer | 10 | 2.3 | 2.10E-01 |
miR-765 | 548 | Cytokine-cytokine receptor interaction | 11 | 2 | 2.00E-01 |
miR-875-5p | 181 | MAPK signaling pathway | 6 | 3.3 | 7.30E-02 |
| Â | Â | Spliceosome | 5 | 2.8 | 2.10E-02 |
miR-940 | - | - | - | - | - |