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  1. The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by excessive apoptosis of ovarian granulosa cells. Acupuncture has been sho...

    Authors: Xiaohong Chen, Hengzhen He, Bingcai Long, Binli Wei, Peng Yang, Xiaoying Huang, Qian Wang, Jing Lin and Hongliang Tang
    Citation: Biological Research 2023 56:31
    Content type: Research article Published on:

  2. Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like phenotype through TGR5-dependent mechanisms. Besi...

    Authors: Johanna Abrigo, Hugo Olguín, Franco Tacchi, Josué Orozco-Aguilar, Mayalen Valero-Breton, Jorge Soto, Mauricio Castro-Sepúlveda, Alvaro A. Elorza, Felipe Simon and Claudio Cabello-Verrugio
    Citation: Biological Research 2023 56:30
    Content type: Research article Published on:

  3. Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for which there is no effective treatment. Previous studies have shown that stem cell transplantation into mdx mice can promote muscle r...

    Authors: Haimei Cen, Pin Fan, Yuting Ding, Bin Luo, Hong Luo, Menglong Chen and Yu Zhang
    Citation: Biological Research 2023 56:29
    Content type: Research article Published on:

  4. Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation. This event causes muscle mass loss and de...

    Authors: Josué Orozco-Aguilar, Franco Tacchi, Francisco Aguirre, Mayalen Valero-Breton, Mauricio Castro-Sepulveda, Felipe Simon and Claudio Cabello-Verrugio
    Citation: Biological Research 2023 56:28
    Content type: Research article Published on:

  5. The underlying mechanism of Parkinson’s disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are trans...

    Authors: Andrea Antonosante, Vanessa Castelli, Martina Sette, Margherita Alfonsetti, Mariano Catanesi, Elisabetta Benedetti, Matteo Ardini, Annamaria Cimini and Michele d’Angelo
    Citation: Biological Research 2023 56:27
    Content type: Research article Published on:

  6. Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic...

    Authors: Qiaoyun Wu, Chenchen Cai, Xinwang Ying, Yujun Zheng, Jiaying Yu, Xiaoxue Gu, Wenzhan Tu, Xinfa Lou, Guanhu Yang, Ming Li and Songhe Jiang
    Citation: Biological Research 2023 56:26
    Content type: Research article Published on:

  7. Mechanoreceptor activation modulates GABA neuron firing and dopamine (DA) release in the mesolimbic DA system, an area implicated in reward and substance abuse. The lateral habenula (LHb), the lateral hypothal...

    Authors: Han Byeol Jang, DanBi Ahn, Suchan Chang, Hyung Kyu Kim, Bong Hyo Lee, Sang Chan Kim, Scott C. Steffensen, Kyle B. Bills, Hubert Lee and Hee Young Kim
    Citation: Biological Research 2023 56:25
    Content type: Research article Published on:

  8. Authors: Ivanka Jiménez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio and Felipe Simon
    Citation: Biological Research 2023 56:24
    Content type: Correction Published on:

    The original article was published in Biological Research 2023 56:8

  9. Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare inherited skin disease caused by variants in the COL7A1 gene, coding for type VII collagen (C7), an important component of anchoring fibrils in the base...

    Authors: Cristian De Gregorio, Evelyng Catalán, Gabriel Garrido, Pilar Morandé, Jimena Castillo Bennett, Catalina Muñoz, Glenda Cofré, Ya-Lin Huang, Bárbara Cuadra, Paola Murgas, Margarita Calvo, Fernando Altermatt, María Joao Yubero, Francis Palisson, Andrew P. South, Marcelo Ezquer…
    Citation: Biological Research 2023 56:23
    Content type: Research article Published on:

  10. The COVID-19 pandemic has caused a large number of diseases worldwide. There are few vaccines to constrain this disease and the value of them is high. In this sense, the antigens of the vaccine platform Sobera...

    Authors: Leina Moro-Pérez, Tammy Boggiano-Ayo, Sum Lai Lozada-Chang, Olga Lidia Fernández-Saiz, Kathya Rashida de la Luz and Jose Alberto Gómez-Pérez
    Citation: Biological Research 2023 56:22
    Content type: Research article Published on:

    The Correction to this article has been published in Biological Research 2024 57:38

  11. Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanism...

    Authors: Felipe Cabezas, Claudio Cabello-Verrugio, Natalia González, Jeremy Salas, Manuel J. Ramírez, Eduardo de la Vega and Hugo C. Olguín
    Citation: Biological Research 2023 56:21
    Content type: Research article Published on:

  12. Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-ind...

    Authors: Xiaojun Zhang, Changsen Wang, Hao Xu, Shuyun Cai, Keyu Liu, Simeng Li, Linming Chen, Siman Shen, Xiaoxia Gu, Jing Tang, Zhengyuan Xia, Zhe Hu, Xiaotang Ma and Liangqing Zhang
    Citation: Biological Research 2023 56:20
    Content type: Research article Published on:

  13. AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle pr...

    Authors: Camilla Maria Fontana, Francesca Terrin, Nicola Facchinello, Giacomo Meneghetti, Alberto Dinarello, Lisa Gambarotto, Annalisa Zuccarotto, Micol Caichiolo, Ginevra Brocca, Ranieri Verin, Francesca Nazio, Oliana Carnevali, Francesco Cecconi, Paolo Bonaldo and Luisa Dalla Valle
    Citation: Biological Research 2023 56:19
    Content type: Research article Published on:

  14. Isolation of nuclei or nuclear proteins is a prerequisite for western blot, nuclear proteome profiling, and other evaluations of nuclear proteins. Here, we developed a simple method for in situ isolation of nu...

    Authors: Ying Qin, Yun Zhou, Kun Wang, Jiaxuan Gu, Zhihao Xiong, Wendiao Zhang and Yong Chen
    Citation: Biological Research 2023 56:18
    Content type: Research article Published on:

  15. Spontaneous spheroid culture is a novel three-dimensional (3D) culture strategy for the rapid and efficient selection of progenitor cells. The objectives of this study are to investigate the pluripotency and d...

    Authors: Ni Li, Xiaofeng Dai, Fei Yang, Yang Sun, Xingwen Wu, Qianrong Zhou, Kai Chen, Jian Sun, Wei Bi, Le Shi and Youcheng Yu
    Citation: Biological Research 2023 56:17
    Content type: Research article Published on:

  16. Diabetes mellitus (DM) is highly susceptible to diabetic hind limb ischemia (DHI). MicroRNA (MiR)-17-5p is downregulated in DM and plays a key role in vascular protection. Endothelial progenitor cell (EPC)-rel...

    Authors: Qunwen Pan, Xiaobing Xu, Wen He, Yan Wang, Zhi Xiang, Xiaojuan Jin, Qiong Tang, Ting Zhao and Xiaotang Ma
    Citation: Biological Research 2023 56:16
    Content type: Research article Published on:

  17. Splenectomy may lead to severe postoperative complications, including sepsis and cancers. A possible solution to this problem is heterotopic autotransplantation of the spleen. Splenic autografts rapidly restor...

    Authors: Andrey Elchaninov, Polina Vishnyakova, Anastasiya Lokhonina, Viktoria Kiseleva, Egor Menyailo, Maria Antonova, Aiaz Mamedov, Irina Arutyunyan, Galina Bolshakova, Dmitry Goldshtein, Xuhui Bao, Timur Fatkhudinov and Gennady Sukhikh
    Citation: Biological Research 2023 56:15
    Content type: Research article Published on:

  18. The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 cannabinoid receptor (CB1). Likewise...

    Authors: Carlos Sepúlveda, Juan Manuel Rodríguez, Matías Monsalves-Álvarez, Camila Donoso-Barraza, Francisco Pino-de la Fuente, Isabelle Matías, Thierry Leste-Lasserre, Philippe Zizzari, Eugenia Morselli, Daniela Cota, Miguel Llanos and Rodrigo Troncoso
    Citation: Biological Research 2023 56:14
    Content type: Research article Published on:

  20. Drought stress has significantly hampered agricultural productivity worldwide and can also result in modifications to DNA methylation levels. However, the dynamics of DNA methylation and its association with t...

    Authors: Ling Wang, Lei Wang, Meilian Tan, Linhai Wang, Wei Zhao, Jun You, Lijun Wang, Xingchu Yan and Wei Wang
    Citation: Biological Research 2023 56:12
    Content type: Research article Published on:

  21. Nonalcoholic fatty pancreatitis (NAFP) is one of the metabolic syndrome manifestations that need further studies to determine its molecular determinants and find effective medications. We aimed to investigate ...

    Authors: Reda Albadawy, Amany Helmy Hasanin, Sara H. A. Agwa, Shaimaa Hamady, Reham Hussein Mohamed, Eman Gomaa, Mohamed Othman, Yahia A. Yahia, Amani Mohamed Abdel Ghani and Marwa Matboli
    Citation: Biological Research 2023 56:11
    Content type: Research article Published on:

  22. The biological tube is a basal biology structure distributed in all multicellular animals, from worms to humans, and has diverse biological functions. Formation of tubular system is crucial for embryogenesis a...

    Authors: Xiuke Ouyang, Bingtong Wu, Haiyan Yu and Bo Dong
    Citation: Biological Research 2023 56:10
    Content type: Research article Published on:

  23. Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the relationship between genomic regions subject to DNA-m...

    Authors: Rodolfo Gómez, Matt J. Barter, Ana Alonso-Pérez, Andrew J. Skelton, Carole Proctor, Gabriel Herrero-Beaumont and David A. Young
    Citation: Biological Research 2023 56:9
    Content type: Research article Published on:

  24. Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated in...

    Authors: Ivanka Jiménez-Dinamarca, Yolanda Prado, Pablo Tapia, Sebastian Gatica, Clemens Alt, Charles P. Lin, Cristian Reyes-Martínez, Carmen G. Feijóo, Cristobal Aravena, Alejandra González-Canacer, Simón Correa, Diego Varela, Claudio Cabello-Verrugio and Felipe Simon
    Citation: Biological Research 2023 56:8
    Content type: Research article Published on:

    The Correction to this article has been published in Biological Research 2023 56:24

  25. The distinct arterial and venous cell fates are dictated by a combination of various genetic factors which form diverse types of blood vessels such as arteries, veins, and capillaries. We report here that YULI...

    Authors: Hsin-Hung Lin, Ming-Wei Kuo, Tan-Chi Fan, Alice L. Yu and John Yu
    Citation: Biological Research 2023 56:7
    Content type: Research article Published on:

  26. Despite representing the largest fraction of animal life, the number of insect species whose genome has been sequenced is barely in the hundreds. The order Dermaptera (the earwigs) suffers from a lack of genom...

    Authors: Sanae Kobayashi, Jonathan E. Maldonado, Alexis Gaete, Ingrid Araya, Constanza Aguado-Norese, Nicolás Cumplido, Sebastián Díaz, Alonso Espinoza, Edelmira Fernández, Felipe Gajardo, Felipe González-Ordenes, Khantati Hauyon, Piedad Maldonado, Rodrigo Maldonado, Isabel Pochet, Aníbal Riveros…
    Citation: Biological Research 2023 56:6
    Content type: Research article Published on:

  27. Alpha‐kinase 1 (ALPK1) is a master regulator in inflammation and has been proved to promote renal fibrosis by promoting the production of IL-1β in diabetic nephropathy (DN) mice. Pyroptosis is involved in high...

    Authors: Xinyuan Cui, Yifu Li, Shuguang Yuan, Yao Huang, Xiaojun Chen, Yachun Han, Zhiwen Liu, Zheng Li, Yang Xiao, Youliang Wang, Lin Sun, Hong Liu and Xuejing Zhu
    Citation: Biological Research 2023 56:5
    Content type: Research article Published on:

  28. Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be disc...

    Authors: Ning Li, Qianyin Zhou, Zhang Yi, Huan Zhang and Dai Zhou
    Citation: Biological Research 2023 56:4
    Content type: Research article Published on:

  29. Contrary to the advantageous anticancer activities of curcumin (Cur), limited bioavailability and solubility hindered its efficacy. Here, nontoxic dendrosomal nano carrier with Cur was used to overcome these p...

    Authors: Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hossein Tarrahimofrad, Javad Zamani, Hamed Haddad Kashani, Ejaz Ahmad and Hossein Nikzad
    Citation: Biological Research 2023 56:3
    Content type: Research article Published on:

  30. The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages of life. Exposure to these threats mainly occurs during cancer treatment and as an occupational hazard in ra...

    Authors: Hamdy Y. Ismail, Nora A. Shaker, Shaymaa Hussein, Adel Tohamy, Mohamed Fathi, Hamdy Rizk and Y. R. Wally
    Citation: Biological Research 2023 56:2
    Content type: Research Article Published on:

  31. Cell cycle is one of the main cellular mechanisms involved in tumor progression. Almost all of the active molecular pathways in tumor cells directly or indirectly target the cell cycle progression. Therefore, ...

    Authors: Amir Sadra Zangouei, Malihe Zangoue, Negin Taghehchian, Alireza Zangooie, Hamid Reza Rahimi, Ehsan Saburi, Mahya Sadat Alavi and Meysam Moghbeli
    Citation: Biological Research 2023 56:1
    Content type: Review Published on:

  32. Based on the inconsistent literature published thus far involving infertile patients, whether intracytoplasmic sperm injection (ICSI) allows overcoming total fertilization failure due to sperm DNA fragmentatio...

    Authors: Jordi Ribas-Maynou, Sergi Novo, Marc Torres, Albert Salas-Huetos, Sergi Rovira, Marta Antich and Marc Yeste
    Citation: Biological Research 2022 55:41
    Content type: Research Article Published on:

  33. Cartilaginous disorders comprise a wide range of diseases that affect normal joint movement, ear and nose shape; and they have great social and economic impact. Mesenchymal stem cells (MSCs) provide a promisin...

    Authors: Taghreed Ahmed Hassan, Mohamed Ahmed Maher, Amr Fekry El Karmoty, Zainab Sabry Othman Ahmed, Marwa A Ibrahim, Hamdy Rizk and Ayman Tolba Reyad
    Citation: Biological Research 2022 55:40
    Content type: Research Article Published on:

  34. Alzheimer’s disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates. Importantly, Aβ and tau species are able to ac...

    Authors: Catalina Novoa, Paulina Salazar, Pedro Cisternas, Camila Gherardelli, Roberto Vera-Salazar, Juan M. Zolezzi and Nibaldo C. Inestrosa
    Citation: Biological Research 2022 55:39
    Content type: Review Published on:

  35. Excitotoxicity-induced in vivo injury models are vital to reflect the pathophysiological features of acute spinal cord injury (SCI) in humans. The duration and concentration of chemical treatment controls the ...

    Authors: Anam Anjum, Yt Jun Cheah, Muhammad Da’in Yazid, Muhammad Fauzi Daud, Jalilah Idris, Min Hwei Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Ismail, Ramesh Kumar Athi Kumar, Geok Chin Tan, Yin Ping Wong, Mohd Kaisan Mahadi and Yogeswaran Lokanathan
    Citation: Biological Research 2022 55:38
    Content type: Research Article Published on:

  36. Diabetes mellitus (DM) has glucose variability that is of such relevance that the appearance of vascular complications in patients with DM has been attributed to hyperglycemic and dysglycemic events. It is kno...

    Authors: Manuel Vásquez-Muñoz, Alexis Arce-Álvarez, Cristian Álvarez, Rodrigo Ramírez-Campillo, Fernando A. Crespo, Dayana Arias, Camila Salazar-Ardiles, Mikel Izquierdo and David C. Andrade
    Citation: Biological Research 2022 55:37
    Content type: Research Article Published on:

  39. The assessment of oocyte quality is, nowadays, a major challenge in aquaculture, oocyte cryopreservation, and environmental science. Oocyte quality is a determining factor in fertilization and embryo developme...

    Authors: Alessandra Gallo, Maria Consiglia Esposito, Raffaele Boni and Elisabetta Tosti
    Citation: Biological Research 2022 55:34
    Content type: Research article Published on:

  40. Ionizing radiations (IR) have widespread useful applications in our daily life; however, they have unfavorable effects on reproductive health. Maintaining testicular health following IR exposure is an importan...

    Authors: Maggie E. Amer, Azza I. Othman, Hajer Mohammed Abozaid and Mohamed A. El-Missiry
    Citation: Biological Research 2022 55:33
    Content type: Research article Published on:

    The Correction to this article has been published in Biological Research 2023 56:39

  41. Designed mimetic molecules are attractive tools in biopharmaceuticals and synthetic biology. They require mass and functional production for the assessment of upcoming challenges in the near future. The DARPin...

    Authors: Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz, Ashraf Gholizadeh, Hamideh Ofoghi and Dariush Shanehbandi
    Citation: Biological Research 2022 55:32
    Content type: Research article Published on:

  42. Genetic modification of living organisms has been a prosperous activity for research and development of agricultural, industrial and biomedical applications. Three decades have passed since the first genetical...

    Authors: Pablo Rozas, Eduardo I. Kessi-Pérez and Claudio Martínez
    Citation: Biological Research 2022 55:31
    Content type: Review Published on:

  43. Xenotransplantation has been primarily performed using fresh donor tissue to study testicular development for about 20 years, and whether the cultured tissue would be a suitable donor is unclear. In this study...

    Authors: Yubo Ma, Juan Chen, Hecheng Li, Fangshi Xu, Tie Chong, Ziming Wang and Liandong Zhang
    Citation: Biological Research 2022 55:30
    Content type: Research article Published on:

  44. Metastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the underlying mechanisms remain elusive. Communication between cancer stem cells...

    Authors: Xiaoshuang Li, Doudou Liu, Hao Chen, Bin Zeng, Qiting Zhao, Yuhan Zhang, Yuting Chen, Jianyu Wang and H. Rosie Xing
    Citation: Biological Research 2022 55:29
    Content type: Research article Published on:

  45. Atopic dermatitis (AD) is highly comorbid with negative emotions such as anxiety and depression. Although acupuncture has demonstrated efficacy in AD, its influence on comorbid anxiety and depression remains u...

    Authors: Mijung Yeom, Sora Ahn, Sun-Young Jang, Jae-Hwan Jang, Youngrye Lee, Dae-Hyun Hahm and Hi-Joon Park
    Citation: Biological Research 2022 55:28
    Content type: Research article Published on:

    The Correction to this article has been published in Biological Research 2022 55:36

  46. Cytokinin signal transduction is mediated by a two-component system (TCS). Two-component systems are utilized in plant responses to hormones as well as to biotic and abiotic environmental stimuli. In plants, resp...

    Authors: Lanjie Zhao, Lixue Guo, Xuke Lu, Waqar Afzal Malik, Yuexin Zhang, Jing Wang, Xiugui Chen, Shuai Wang, Junjuan Wang, Delong Wang and Wuwei Ye
    Citation: Biological Research 2022 55:27
    Content type: Research article Published on:

  47. Unsubstantiated concerns have been raised on the potential correlation between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and infertility, leading to vaccine hesitancy in reproduc...

    Authors: Jialyu Huang, Leizhen Xia, Lifeng Tian, Hancheng Fan, Dingfei Xu, Xiaoyan Ai, Xingwu Wu, Jia Chen, Genbao Xing, Lingling Huang, Huijun Zuo, Jia Chen, Mengxi Li, Ke Zhang, Peipei Liu, Jiaying Lin…
    Citation: Biological Research 2022 55:26
    Content type: Research article Published on:

  49. Recent advances in the synthesis of bioactive nanoparticles resulted in the discovery and introduction of new bioactive nanoparticles to the pharmaceutical industry. In this regard, this research is aimed to s...

    Authors: Ghasem Rahimi, Kalateh Shah Mohammad, Mahsa Zarei, Mohammad Shokoohi, Ehsan Oskoueian, Mahsa Rastegar Moghaddam Poorbagher and Ehsan Karimi
    Citation: Biological Research 2022 55:24
    Content type: Short report Published on:

  50. Human Gut Microbiota (HGM) is composed of more than one thousand species, playing an important role in the health status of individuals. Dysbiosis (an HGM imbalance) is augmented as chronic kidney disease (CKD...

    Authors: María V. Miranda, Fernanda C. González, Osvaldo S. Paredes-Godoy, Mario A. Maulén, Claudio C. Vásquez† and Waldo A. Díaz-Vásquez
    Citation: Biological Research 2022 55:23
    Content type: Research article Published on:
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