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Fig. 7 | Biological Research

Fig. 7

From: Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors

Fig. 7

Effects of mechanical stimulation and optogenetic inhibition on c-Fos expression in the LHb. A Experimental schedule. B Schematic for virus injection and optogenetics in LHb. C Mean numbers of the c-Fos positive neurons in the LHb in each group. ***P < 0.001, Control versus MS; ###P < 0.001, MS versus MS + NpHR (ON); @@@P < 0.001, MS + NpHR (ON) versus ChR (ON). D Verification of virus injection site on the end of experiment. E Representative image of c-Fos expression in the LHb in control group (n = 6), MS group (n = 6), MS + NpHR (ON) group (n = 6), and ChR (ON) group (n = 6). Bar = 50 µm. MS, mechanical stimulation of ulnar nerve. ON, switch on the laser light. OFF, switch off the laser light

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