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Fig. 5 | Biological Research

Fig. 5

From: Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors

Fig. 5

Effect of LH-LHb inhibition with DREADDi on cocaine-induced 50 kHz USVs and locomotion. A Experimental schedule and schematics for chemogenetic inhibition of LH-LHb pathway. B Effect of LH-LHb inhibition with DREADDi on cocaine-induced 50 kHz USVs. *P < 0.001 CNO versus Veh + MS; #P < 0.001, CNO + MS versus Veh + MS. n = 6 per group. C, D Effect of LH-LHb inhibition with DREADDi on cocaine-induced locomotor activity. *P < 0.001 CNO versus Veh + MS; #P < 0.001, CNO + MS versus Veh + MS. Representative moving traces for 60 min after treatments of cocaine, CNO or CNO + MS; CNO + MS, CNO injection before MS in cocaine-injected rats; Veh + MS, aCSF injection before MS in cocaine-injected rats. E Viral DREADDi expression in LH or LHb. MS, mechanical stimulation of ulnar nerve. n = 6 per group

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Biological Research

ISSN: 0717-6287

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