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Fig. 2 | Biological Research

Fig. 2

From: Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors

Fig. 2

Mediation of LHb in MS inhibition of cocaine-induced DA release in the NAc. A Schematic of fast-scan cyclic voltammetry (FSCV) for recording NAc DA release. B Effect of MS on cocaine enhancement of electrically stimulated DA release in NAc in normal rats (n = 6 per group). *P < 0.05 versus Control (normal rats). C–E Representative voltammograms and representative voltammetry pseudocolor images for each group. F Schematic of FSCV for recording NAc DA release in LHb-lesioned rats. G Effect of LHb lesions on MS inhibition of electrically stimulated-DA release in NAc (n = 6 per group). H–J Representative voltammograms and representative voltammetry pseudocolor images for each group. NAc, nucleus accumbens; DA, dopamine; MFB, medial forebrain bundle; Control, cocaine injection only; cocaine + MS, mechanical stimulation of ulnar nerver in cocaine-injected rats; LHb X, lesion of lateral habenula; LHb X + MS, MS after cocaine injection in LHb-lesioned rats. MS, mechanical stimulation of ulnar nerve

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