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Fig. 9 | Biological Research

Fig. 9

From: Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson’s disease models

Fig. 9

(A) Experimental design. (B) Cylinder test, (C) EBS test and (D) Apomorphine induced rotation test in SHAM, 6-OHDA, 6-OHDA + GSK0660 AND GSK0660 animals. Transverse section taken through the striatum (E), immunostained for TH to evaluate the dopaminergic-induced injury by stereotaxic injection of 6-OHDA in the right side. Histograms shows the percentage of TH + fibers loss in striatum (CPu) (expressed in percentage of unlesioned side). (F) Western blotting and relative densitometric analysis for TH in the striatum. Transverse section taken through substantia nigra pars compacta (G), immunostained for TH to evaluate the dopaminergic-induced injury by stereotaxic injection of 6-OHDA in the right side. Histogram shows the TH + cell bodies in substantia nigra (SN) (expressed in percentage of unlesioned side). *** p < 0.0005, vs. CTR; +++ p < 0.0005, ++ p < 0.005 vs. 6-OHDA

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Biological Research

ISSN: 0717-6287

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