Fig. 2
From: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
TRPM7 α-kinase domain participation in endotoxin-induced platelet and neutrophil adhesion to endothelial cells. Vehicle- and endotoxin-treated ECs exposed to saline solution or the TRPM7 α-kinase function inhibitor TG100-115, and then cocultured with platelets (A) or neutrophils (B) for 24 h. (N = 3–4). Results were normalized against vehicle-exposed cells (control condition). Statistical differences were assessed by a two-way analysis of variance (ANOVA) followed by Tukey post hoc test. ****p < 0.0001, compared with the saline-treated condition. Results showed as mean ± SEM