Fig. 11

TRPM7 expression increases in CMECs and CEPCs from SSPs, which correlates with DIC and survival time. A Experimental strategy for SSPs (N = 22) and HVs (N = 25). TRPM7 mRNA and protein expression in CMECs (B) and CEPCs (C) extracted from HVs (grey circles) and SSPs (red circles). Statistical differences were assessed by student’s t-test (Mann–Whitney) (N = 16) *p < 0.05, **p < 0.01, ***p < 0.001, compared with the saline-treated condition. Results showed as mean ± SEM. Determination of ISTH-DIC Score in HVs (grey circles) and SSPs (red circles) (D). Statistical differences were assessed by student’s t-test (Mann–Whitney) (N = 16). ****p < 0.0001, compared with the HV group. Results showed as mean ± SEM. Correlation analyses between TRPM7 mRNA and protein expression with ISTH-DIC Score in CMECs (E) and CEPCs (F) extracted from SSPs. Correlation analyses between ISTH-DIC Score with survival time of non-surviving SSPs (G). The relationships between variables were assessed by means of correlation analysis using Spearman’s. TRPM7 mRNA and protein expression in CMECs (H) and CEPCs (I) extracted from surviving (grey circles) and non-surviving SSPs (red circles). Statistical differences were assessed by student’s t-test (Mann–Whitney) (N = 16) *p < 0.05, **p < 0.01, ***p < 0.001, compared with the survivor patients’ group. Results showed as mean ± SEM. Correlation analyses between TRPM7 mRNA and protein expression with survival time in CMECs (J) and CEPCs (K) of non-surviving SSPs. The relationships between variables were assessed by means of correlation analysis using Spearman’s