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Fig. 5 | Biological Research

Fig. 5

From: Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model

Fig. 5

EPC-EXsmiR-17-5p increased viability, while reduced apoptosis of Hypoxia plus HG-injured ECs via activating PI3K/Akt pathway. A Representative images and summary data of apoptosis in ECs. B The viability of ECs. C Representative images and summary data of necrosis in ECs (YO-PRO-1, green; PI, red), Scale bar: 100 μm. D The levels of Cleaved caspase-3 and Cleaved caspase-9 in ECs after incubated with EPC-EXs, EPC-EXsmiR-17-5p, and EPC-EXsmiR-17-5p + LY294002. *p < 0.05 compared with the Sham group; #p < 0.05 compared with PBS group; +p < 0.05 compared with EPC-EXs group; −p < 0.05 compared with EPC-EXs.miR-17-5p group (A–D Two-way ANOVA, followed by Tukey’s post hoc test. Data represent the mean ± SEM, n = 3/group)

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