Fig. 6From: Betahistine alleviates benign paroxysmal positional vertigo (BPPV) through inducing production of multiple CTRP family members and activating the ERK1/2-AKT/PPARy pathwayOverexpression of CTRP1 and 12 promotes phosphorylation of ERK1/2 and AKT and expression of PPARγ. Mice of vestibular dysfunction vertigo were injected with pSB-T-CTRP1, 12 or pSB-T empty vector, respectively. A and B We detected the protein levels of p-ERK1/2 (C) and p-AKT (D) by using western blotting and evaluated the mRNA (E) and protein expression levels of PPARγ (F). N = 3, Statistical differences were performed by using the Student’s t-test. *P < 0.05, **P < 0.01Back to article page