Fig. 5

Silencing CTRP1, 3, 6, 9 and 12 exacerbates vestibular dysfunction in mice. Mice of vestibular dysfunction vertigo were injected with si-CTRP1, 3, 6, 9, 12 or their scrambled, respectively. RT-qPCR was used to detect the mRNA expression of CTRP1 (A), CTRP3 (B), CTRP6 (C), CTRP9 (D) and CTRP12 (E). F and G Western blotting was used to evaluate the protein expression levels of CTRP1, 3, 6, 9 and 12. The scores of head tilt and swimming behavior were detected in mice treated with si-CTRP1 (H), si-CTRP3 (I), si-CTRP6 (J), si-CTRP9 (K) and si-CTRP12 (L), respectively. N = 3, Statistical differences were performed by using the Student’s t-test. *P < 0.05, **P < 0.01