|
Number of risk alleles(a)
|
Controls (n = 1258) (%)
|
All BC cases (n = 486)
|
Families with ≥ 2 BC and/or OC cases (n = 308)
|
Families with a single case, diagnosis at ≤ 50 years of age (n = 178)
|
|---|
|
BC cases (%)
|
OR [95% CI]
|
p-value valueb
|
BC cases (%)
|
OR [95% CI]
|
p-valueb
|
BC cases (%)
|
OR [95% CI]
|
p-valueb
|
|---|
|
0 risk alleles
|
664 (52.8)
|
238 (49.0)
|
1.0 (Ref.)
|
–
|
145 (47.1)
|
1.0 (Ref.)
|
–
|
93 (52.2)
|
1.0 (Ref.)
|
–
|
|
1 risk allele
|
442 (35.1)
|
162 (33.3)
|
1.0 [0.8–1.2]
|
0.85
|
100 (32.5)
|
1.0 [0.7–1.3]
|
0.82
|
62 (34.8)
|
1.0 [0.7–1.4]
|
1.00
|
|
2 risk alleles
|
132 (10.5)
|
76 (15.6)
|
1.6 [1.1–2.2]
|
0.004
|
56 (18.2)
|
1.9 [1.3–2.7]
|
0.0006
|
20 (11.2)
|
1.0 [0.6–1.8]
|
0.78
|
|
3 risk alleles
|
19 (1.5)
|
7 (1.4)
|
1.0 [0.4–2.4]
|
1.00
|
4 (1.3)
|
1.0 [0.3–2.8]
|
1.00
|
3 (1.7)
|
1.1 [0.3–3.8]
|
0.74
|
|
4 risk alleles
|
1 (0.1)
|
3 (0.6)
|
8.3 [0.8–80.9]
|
0.05
|
3 (1.0)
|
13.7 [0.4–133.1]
|
0.02
|
0 (0.0)
|
2.3 [0.09–58.6]
|
1.00
|
|
p-trend(c)
| | | |
0.01
| | |
0.001
| | |
0.81
|
|
Global p (d)
| | | |
0.009
| | |
0.0002
| | |
0.99
|
- (a) 0 risk alleles: A/A + G/G; 1 risk allele: A/A + G/C, A/G + G/G; 2 risk alleles: A/A + C/C, G/G + G/G, A/G + G/C; 3 risk alleles: A/G + C/C, G/G + A/C; 4 risk alleles: G/G + C/C.; (b) Fisher’s exact test; (c) Chi-test for trend; (d) Chi-squared test for independence
- BC breast cancer, OC ovarian cancer, OR odds ratio, CI confidence interval, Ref reference
- Bold values are statistically significant (p < 0.05)
