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Table 3 Combined effect of rs12366395 (TBX3) and rs72758040 (MAP3K1) on breast cancer risk

From: Heritable genomic diversity in breast cancer driver genes and associations with risk in a Chilean population

Number of risk alleles(a) Controls (n = 1258) (%) All BC cases (n = 486) Families with ≥ 2 BC and/or OC cases (n = 308) Families with a single case, diagnosis at ≤ 50 years of age (n = 178)
BC cases (%) OR [95% CI] p-value valueb BC cases (%) OR [95% CI] p-valueb BC cases (%) OR [95% CI] p-valueb
0 risk alleles 664 (52.8) 238 (49.0) 1.0 (Ref.) 145 (47.1) 1.0 (Ref.) 93 (52.2) 1.0 (Ref.)
1 risk allele 442 (35.1) 162 (33.3) 1.0 [0.8–1.2] 0.85 100 (32.5) 1.0 [0.7–1.3] 0.82 62 (34.8) 1.0 [0.7–1.4] 1.00
2 risk alleles 132 (10.5) 76 (15.6) 1.6 [1.1–2.2] 0.004 56 (18.2) 1.9 [1.3–2.7] 0.0006 20 (11.2) 1.0 [0.6–1.8] 0.78
3 risk alleles 19 (1.5) 7 (1.4) 1.0 [0.4–2.4] 1.00 4 (1.3) 1.0 [0.3–2.8] 1.00 3 (1.7) 1.1 [0.3–3.8] 0.74
4 risk alleles 1 (0.1) 3 (0.6) 8.3 [0.8–80.9] 0.05 3 (1.0) 13.7 [0.4–133.1] 0.02 0 (0.0) 2.3 [0.09–58.6] 1.00
p-trend(c)     0.01    0.001    0.81
Global p (d)     0.009    0.0002    0.99
  1. (a) 0 risk alleles: A/A + G/G; 1 risk allele: A/A + G/C, A/G + G/G; 2 risk alleles: A/A + C/C, G/G + G/G, A/G + G/C; 3 risk alleles: A/G + C/C, G/G + A/C; 4 risk alleles: G/G + C/C.; (b) Fisher’s exact test; (c) Chi-test for trend; (d) Chi-squared test for independence
  2. BC breast cancer, OC ovarian cancer, OR odds ratio, CI confidence interval, Ref reference
  3. Bold values are statistically significant (p < 0.05)