Table 1 Summary of previous studies on osteogenic differentiation of MSCs
From: The therapeutic potential of mesenchymal stem cells in treating osteoporosis
Author, reference | Cell type | Animal model | Condition | Intervention | Consequence |
|---|---|---|---|---|---|
Takada et al. [60] | BMSCs | SAMP6 mice | Irradiated | Injection | BM microenvironment normalized and trabecular bone increased |
Ocarino Nde M.et al. [61] | BMSCs | Female Wistar rats | Ovariectomy | Injection | Trabecular bone percentage increased |
Huang et al. [62] | BMSCs | Sprague–Dawley rats | Femoral fracture | Injection | Larger callus size and higher mechanical property |
Hu et al. [64] | BMSCs | Rats | Osteogenic differentiation | Treated with MOTS-c | MOTS-c promoting osteogenic differentiation via TGF-β/Smad pathway |
Wang et al. [65] | BMSCs | Sprague–Dawley rats | Ovariectomy | Transfected with pcDNA-GGCX | Reduced GGCX inhibiting osteogenic differentiation via TGFβ/smad pathway |
Ren et al. [66] | BMSCs | Rats | Ovariectomy | Treated with PAAE | PAAE inducing osteogenic differentiation via BMP-2/Smad1,5/Runx2 pathway |
Feng et al. [67] | BMSCs | Sprague–Dawley rats | Ovariectomy | Treated with simvastatin | Simvastatin promoting osteogenic differentiation via BMP-2/Smads pathway |
Zhao et al. [68] | BMSCs | Rats | MSC-Exo | Co-culture of MSC-Exo and hFOB 1.19 | MSC-Exo promoting osteogenic differentiation via MAPK pathway |
Chen et al. [79] | AD-MSCs | Patients | Subculture | Osteogenic induction | Osteogenic differentiation of AD-MSCs less affected by age and multiple passage |
Wang et al. [81] | AD-MSCs | Female C57BL/6 mice | Ovariectomy | Osteogenic induction | Osteogenic potential of AD-MSCs impaired in osteoporotic mice |
Ye et al. [82] | AD-MSCs | Rabbits | Ovariectomy | Osteogenic induction | Stimulating osteogenic differentiation and enhancing bone regeneration |
Jin et al. [84] | hAD-MSCs | Mice | Ovariectomy | Knockdown or overexpression of HSPB7 by lentivirus transfection | HSPB7 negatively regulating osteogenic differentiation of hAD-MSCs |
Zhou et al. [86] | AD-MSCs | AD-MSCs | Oxidative stress | Transinfected with Let-7c inhibitor | Let-7c inhibiting osteogenic differentiation of AD by targeting SCD-1 |
Ding et al. [88] | AD-MSCs | Canines | Bone defect | Treated with AD-MSCs plus PRF | PRF enhancing osteogenic potential of AD-MSCs |
Na et al. [99] | hUC-MSCs | hUC-MSCs | hUC-MSCs | Treated with GSI-I | GSI-I reducing osteogenic differentiation of hUC-MSCs |
Qu et al. [100] | hUC-MSCs | SD rats | Fracture nonunion | AKT blocker injection | AKT modulating osteogenesis induced by hUC-MSCs |
Liu et al. [101] | UC-MSCs | Mice | CIA | Transplantation | Upregulating the impaired osteogenic differentiation ability in CIA mice |
Liang et al. [104] | hUC-MSCs | Aged rats | Age-related osteoporosis | Treated with secretome | Secretome from hUC-MSCs having the capacity to recover stem cell potential |
Wang et al. [108] | hUC-MSCs | hBMSCs | Without OIM | Treated with secretion factors | Initiating osteogenic differentiation of hBMSCs without OIM |
Hendrijantini et al. [111] | hUC-MSCs | Female Wistar rats | Ovariectomy | Injection | Increasing osteogenic differentiation and osteoporotic mandibular bone density |