PMID/author/year | Age at surgery, sex, animal supplier | Exercise start, exercise regime | TAC type | n | LV hypertrophy normalized to sham (%) | Cardiac characteristics at sacrifice | Muscle characteristics at sacrifice |
---|---|---|---|---|---|---|---|
28622359/Wang et al./2017 | 8 weeks, male, Jackson Lab | Start: 1 week post-surgery Regime: swimming with increasing training duration (20–60 min/day), 60% VO2max, 9 weeks | Sham sed | 15 | 100 | EF = 75%a, FS = 37%a | No muscle characteristics specified |
Sham ex | 15 | 100a | EF = 80%a, FS = 40%a | No muscle characteristics specified | |||
TAC 27G sed | 15 | 153 | EF = 40%a. FS = 18%a. ~ 3-fold increased CSA, 12% interstitial fibrotic remodeling (Masson Trichrome staining) | No muscle characteristics specified | |||
TAC 27G ex | 15 | 132 | EF = 57%. FS = 25%. ~ 2-fold increased CSA. 4% interstitial fibrotic remodeling (Masson Trichrome staining) | No muscle characteristics specified | |||
31930683/Tian et al./2019 | 6 weeks, male, Shanghai Lab Animal Center | Start: n.d Regime: Treadmill running with increasing intensity (30–60 min/day, 11–13 m/min), 8 weeks | Sham sed | 100a | EF = 64%a, FS = 38%a | No muscle characteristics specified | |
Sham ex | 100a | EF = 70%a, FS = 40%a | No muscle characteristics specified | ||||
TAC 27G sed | 159a | EF = 50%a. FS = 23%a. ~ 1.4-fold increased CSAa, 2.8-fold increased ANPa, 3.5-fold increased BNPa | No muscle characteristics specified | ||||
TAC 27G ex | 140a | EF = 58%. FS = 30%. ~ 1.2-fold increased CSAa, twofold increased ANPa, 2.5-fold increased BNPa | No muscle characteristics specified | ||||
21291889/Van Deel et al./2011 | 20 weeks, sex not specified, supplier not specified | Start: immediately post-surgery Regime: 8 weeks voluntary wheel running | Sham sed | 20 | 100 | FS = 38%a | |
Sham ex | 21 | 105a | FS = 40%a | Total run distance 432 ± 37 km | |||
TAC 25G sed | 16 | 120a | FS = 32%a | ||||
TAC 25G ex | 13 | 140 | FS = 31%a | Total run distance 409 ± 42 km | |||
TAC 27G sed | 35 | 186 | FS = 17%a | ||||
TAC 27G ex | 29 | 200a | FS = 14%a | Total run distance 276 ± 38 km | |||
23449942/Richards et al./2013 | 8 weeks, male, Jackson Lab | ETT at 3, 7, 11, 15 weeks post-surgery | Sham | 10 | 100 | EF = 72 ± 4% | Maximum running distance at 3, 7, 11, 15 weeks: 630 ma, 410 ma, 390 ma, 400 ma |
LAD | 34 | 147 | EF = 36 ± 5%. Interstitial fibrotic remodeling (Masson Trichrome staining) | Maximum running distance at 3, 7, 11, 15 weeks: 490 ma, 380 ma, 400 ma, 390 ma | |||
TAC 27G | 16 | 197 | EF = 28 ± 6%. Interstitial fibrotic remodeling (Masson Trichrome staining) | Maximum running distance at 3, 7, 11, 15 weeks: 400 ma, 300 ma, 300 ma, 280 ma | |||
29986381/Van Deel et al./2018 | 12–20 weeks, sex not specified, supplier not specified | Start: immediately post-surgery Regime: 8 weeks voluntary wheel running | Sham sed | 12 | 100 | FS = 38%a | |
Sham ex | 12 | 100 | FS = 40%a | Total run distance: 435 ± 6 km | |||
LAD sed | 21 | 110a | FS = 10%a, collagen content ~ 1.8%a increased | ||||
LAD ex | 19 | 105a | FS = 15%a | Total run distance: 245 ± 5 km | |||
TAC sed, needle diameter not specified (presumably 27G) | 19 | 200a | FS = 15%a, collagen content ~ 2% increased | ||||
TAC ex, needle diameter not specified (presumably 27G) | 16 | 210a | FS = 13%a, collagen content ~ 3.7%a increased | Total run distance: 237 ± 6 km | |||
28159807/Sung et al./2017 | 8 weeks, male, Charles River Lab | ETT: treadmill running at 15 m/min, 3 and 5 weeks post TAC | Sham | 15 | 100 | EF = 50.08 ± 5.01%, FS = 25.73 ± 3.25% 5 weeks post TAC | Total run distance: 490 ma, whole body glucose consumption: 4.900 mL/kg/ha and fatty acid oxidation: 600 mL/kg/ha, O2 consumption in EDL (a) basal: 2.1 nmol O2/min/mg dry wta, (b) ADP-stimulated: 6.1 nmol O2/min/mg dry wta O2 consumption in Soleus (a) basal: 3 nmol O2/min/mg dry wta, (b) ADP-stimulated: 2 nmol O2/min/mg dry wta All data 5 weeks post TAC |
TAC 27G | 10 | 172 | EF = 26.00 ± 3.47%, FS = 12.21 ± 1.78% 5 weeks post TAC | Total run distance: 260 ma, reduced activity in insulin pathway in skeletal muscle, whole body glucose consumption: 1.900 mL/kg/ha and fatty acid oxidation: 800 mL/kg/ha, O2 consumption in EDL (a) basal: 1.3 nmol O2/min/mg dry wta, (b) ADP-stimulated: 3 nmol O2/min/mg dry wta O2 consumption in Soleus (a) basal: 10 nmol O2/min/mg dry wta, (b) ADP-stimulated: 4.9 nmol O2/min/mg dry wta All data 5 weeks post TAC | |||
Own data | 8 weeks, male, Janvier Lab | Start: 2 weeks post-surgery Regime: 8 weeks treadmill training at 60% VO2max | Sham | 13 | 100 | EF = 61 ± 5%, FS = 32 ± 3% | EDL maximum force 25.8 ± 5.7 N/cm2 |
TACSED 27G | 11 | 147 | EF = 46 ± 6%, FS = 23 ± 4%, 1.2-fold increased CSA | EDL maximum force 28.8 ± 4.7 N/cm2 EDL: 1.2-fold decreased CSA, 1.25-fold decrease in slow fibers Soleus: CSA as in sham, 1.1-fold increase in slow fibers | |||
TACEX 27G | 12 | 140 | EF = 47 ± 7%, FS = 23 ± 4%, 1.2-fold increased CSA | EDL maximum force 28.1 ± 6.6 N/cm2 EDL: 1.1-fold decreased EDL CSA, 1.2-fold decrease in slow fibers Soleus: 1.2-fold decreased Soleus CSA, slow fibers as in sham |