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Table 4 Allele or genotype associated with breast cancer risk in miRNA SNPs included in this review

From: Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review

BC risk category miRNA SNP(s) Risk allele or genotype p-value Countries References
Increased risk 146a rs2910164:G > C C
CG and GG
C
CC
C
C
GC and CC
CC
0.03
< 0.05
0.04
< 0.001
0.03
0.0037
0.033 and 0.028
< 0.0001
Brazil
China
China
Iran
Iran
Iran
Italy
Pakistan
Brincas et al. 2020 [109]
He et al. 2015 [56]
Qi et al. 2015 [55]
Mashayekhi et al. 2018 [69]
Parchami Barjui et al. 2017 [76]
Meshkat et al. 2016 [83]
Pastrello et al. 2010 [98]
Ahmad et al. 2019 [91]
196a2 rs11614913:C > T T
CT
C
C
C
CT
0.024
0.04
0.01
0.011
0.02236
0.01
Brazil
India
China
China
Iran
Saudi Arabia
Linhares et al. 2012 [108]
Bodal et al. 2017 [68]
Qi et al. 2015 [55]
Hu et al. 2009 [59]
Najeti-Azar et al., 2018 [72]
Alshtawi et al. 2012 [87]
499 rs3746444:T > C or A > G AG and GG
G
C
C
G
C
0.008
0.025
0.001
0.034
0.02952
0.001
China
China
Iran
Iran
Iran
Saudi Arabia
Dai et al. 2016 [57]
Hu et al. 2009 [59]
Omrani et al. 2014 [70]
Afsharzadeh et al., 2017 [77]
Kabirizadeh et al., 2016 [79]
Alshtawi et al. 2012 [87]
218-2 rs11134527:A > G G < 0.0001 Iran Danesh et al. 2018 [74]
301-b rs384262G > A A < 0.0001 Iran Danesh et al. 2018 [74]
605 rs2043556T:A > G G 0.00003 Iran Kazemi et al. 2020 [75]
599 rs58450758:C > T CT and TT < 0.0001 Iran Bahreini et al. 2019 [81]
423 rs6505162:C > A A
T
0.02
0.0001
Chile
Saudi Arabia
Morales et al. 2016 [106]
MiR et al. 2018 [88]
513a-2 rs2018562:A > G G 0.03 USA Yao et al. 2013 [101]
106b rs1527423:A > G G 0.02 USA Yao et al. 2013 [101]
182 rs4541843:C > T T 0.01 Chile Morales et al. 2018 [107]
101-2 rs462480:A > C
rs105387:C > G
C
G
0.017
0.010
China Chen et al. 2014 [65]
Let-7 rs13293512:T > C C 0.013 China Sun et al., 2019 [64]
331 rs1110793:A > G G 0.02 USA Yao et al. 2013 [101]
544 rs10144193:A > T T 0.004 USA Yao et al. 2013 [101]
487 rs1951032G > A A 0.001 USA Yao et al. 2013 [101]
659 rs5750504:T > A A 0.03 USA Yao et al. 2013 [101]
618 rs2682818C > A CA 0.03 Chile Morales et al. 2016 [106]
Decreased risk 27a rs895819:A > G or T > C GG
G
G
G
G
T
0.01
0.032
0.0287
< 0.001
0.001
0.013
Chile
China
Germany
Iran
Iran
Israel
Morales et al. 2016 [106]
Zhang et al. 2013 [58]
Yang et al. 2010 [93]
Mashayekhi et al. 2018 [69]
Parchami Barjui et al. 2017 [76]
Kontorovich et al. 2010 [86]
499 rs3746444:T > C C 0.003 Iran Doulah et al. 2018 [71]
608 rs4919510:C > G G 0.024 Iran Hashemi et al. 2016 [80]
520f rs75598818:G > A GA 0.041 Iran Meshkat et al. 2018 [82]
196a2 rs11614913:C > T CC
T
T
T
0.009
0.0005
0.002
0.00295
Brazil
China
USA
Vietnam
Linhares et al. 2012 [108]
Dai et al. 2016 [57]
Hoffman et al. 2009 [100]
Mihn et al. 2018 [90]
758 rs12586258:G > A A 0.01 USA Yao et al. 2013 [101]
100 rs1834306:G > A A 0.02 USA Yao et al. 2013 [101]
185 rs2008595:C > T
rs887205:A > G
TT
GG
0.04
0.03
USA Bensen et al. 2013 [102]
423 rs6505162:A > C CC 0.035 Australia Smith et al. 2012 [104]
605 rs2043556:T > C C 0.02 Chile Morales et al. 2018 [107]
146a rs2910164:G > C C 0.01 India Bansal et al. 2014 [67]
149 rs2292832:T > C CC 0.053 China He et al. 2015 [56]
30a rs763354:G > A A 0.022 China Zhou et al. 2020 [66]