Fig. 7From: DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy miceDAC treatment inhibited PPARα methylation and reduced damage of retinal tissues in DR mice. DR mouse model was established by intraperitoneal injection of STZ. DAC mice were received intraperitoneal injection of DAC. Normal mice served as control. A HE staining was performed to assess the pathological changes of retinal tissues. B The methylation levels of PPARα in retinal tissues were detected by MSP. QRT-PCR (C) and WB (D) were performed to assess the gene and protein expression of PPARα in retinal tissues. L marker, M methylation, U unmethylation.*P < 0.05 vs. Control; #P < 0.05 vs. DRBack to article page