Fig. 5

Downregulation of circ_0008285 suppresses proliferation, migration, and invasion of HTR-8/SVneo cells under high glucose condition. a Confirmed inhibition effect of siRNAs on the circ_0008285 expression in HTR-8/SVneo cells. b Confirmation of the expression of circ_0008285 in the supernatant after HTR-8/SVneo cells transfection with siRNAs. c Silencing of circ_0008285 inhibits the proliferation of HTR-8/SVneo cells cultivated in high glucose medium. d EdU staining confirms the inhibition effects of HTR-8/SVneo cell proliferation by silencing circ_0008285 under high glucose treatment. e Silencing of circ_0008285 inhibits the migration and invasion of HTR-8/SVneo cells in high glucose. NC, siNC. Mean ± SEM (n = 3), *P < 0.05, **P < 0.01, ****P < 0.0001