Fig. 1

Differentially expressed circular RNAs (circRNAs) in the plasma. a Hierarchical cluster analysis of differential circRNAs. The color scale of the strips runs from green (low relative expression) to red (high relative expression). b Volcano map visualizing the differentially expressed circRNAs in the plasma. The red and green plots represent the significantly differentially expressed upregulated and downregulated circRNAs, respectively (log2 [fold change] ≥ 0.67, P < 0.05). c The chromosome distributions of differentially expressed circRNAs. The red and green bands indicate the distribution of upregulated and downregulated circRNAs in the chromosomes, respectively. d Length enrichment distribution map of differentially expressed circRNAs. The length of the significantly differentially expressed circRNA is mainly within 500 bp. e The KEGG pathway enrichment analysis of parent gene with significantly differentially expressed circRNAs