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Table 1 Association of NOD1 rs2075820 with gastric cancer

From: NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori

Ā 

Cases

Controls

OR (95% CI)a

P-valuea

OR (95% CI)b

P b

All subjects

Ā All samples

297c

Ā 

1.29 (0.96ā€“1.72)

0.092

1.29 (0.92ā€“1.72)

0.095

Ā Intestinal-type

157

Ā 

1.08 (1.08ā€“2.14)

0.016

1.55 (1.10ā€“2.20)

0.013

Ā Diffuse-type

140

Ā 

1.07 (0.74ā€“1.55)

0.732

1.29 (0.96ā€“1.72)

0.095

H. pylori-positive

Ā All samples

102

102

1.88 (1.08ā€“3.24)

0.02

1.70 (0.96ā€“3.00)

0.07

Ā Intestinal-type

50

102

2.69 (1.41ā€“5.13)

2.6ā€‰Ć—ā€‰10 āˆ’3

2.50 (1.26ā€“4.96)

0.01

Ā Diffuse-type

52

102

1.26 (0.63ā€“2.52)

0.51

1.23 (0.61ā€“2.48)

0.56

H. pylori cag PAI-positive

Ā All samples

87

43

4.90Ā  (1.80ā€“13.36)

1.9ā€‰Ć—ā€‰10 āˆ’3

4.32 (1.57ā€“11.89)

4.6ā€‰Ć—ā€‰10āˆ’3

Ā Intestinal-type

42

43

7.16 (2.40ā€“21.33)

4.1ā€‰Ć—ā€‰10 āˆ’4

6.77 (2.18ā€“21.02)

9.5ā€‰Ć—ā€‰10 āˆ’4

Ā Diffuse-type

45

43

3.39 (1.13ā€“10.10)

0.03

3.20 (1.06ā€“9.67)

0.04

  1. aUnadjusted
  2. bAdjusted for sex, principal component (PC)1 and PC2. OR: odds ratio. 95% CI: 95ā€‰% confidence interval. Statistically significant results are shown in bold (Significance level after Bonferroniā€™s correctionā€‰<ā€‰2.9ā€‰Ć—ā€‰10āˆ’3)
  3. cTwo cases with no-defined adenocarcinoma