Skip to main content
Fig. 6 | Biological Research

Fig. 6

From: LncRNA MALAT1 aggravates oxygen‐glucose deprivation/reoxygenation-induced neuronal endoplasmic reticulum stress and apoptosis via the miR-195a-5p/HMGA1 axis

Fig. 6

LncRNA-MALAT1 regulates neuron function via its downstream effector HMGA1. a Transfection of HT22 cells with pcDNA3.1-HMGA1 significantly promotes the expression of HMGA1 as determined by qRT-PCR. b The expression of HMGA1 in HT22 cells, examined by qRT-PCR. c Transfection of HT22 cells with pcDNA3.1-HMGA1 significantly abolished the promotion effect of MALAT1 siRNA on cell viability as determined by CCK8 assay. d, e Transfection of HT22 cells with pcDNA3.1-HMGA1 significantly abolished the inhibition effect of MALAT1 siRNA on cell apoptosis as determined by flow cytometry analysis. f Transfection of HT22 cells with pcDNA3.1-HMGA1 significantly abolished the inhibition effect of MALAT1 siRNA on the expression of GRP78 and CHOP as determined by westen blot analysis. g Transfection of HT22 cells with pcDNA3.1-HMGA1 significantly abolished the inhibition effect of MALAT1 siRNA on the expression of GRP78 and CHOP as determined by immunofluorescent staining. n = 3. **p < 0.01 versus the OGD/R groups. ##p < 0.01 versus the OGD/R + si-MALAT1 groups

Back to article page

Biological Research

ISSN: 0717-6287

Contact us