Fig. 4

Summary of gene ontology enrichment analysis of differently expressed proteins after prolonged maternal separation. GO enrichment analysis was conducted using the Gorilla tool (http://cbl-gorilla.cs.technion.ac.il/) on 2735 proteins altered at least in one of nine pairwise comparisons. The GO terms in biological processes with p-value < 10^–5 were analyzed. The color indicates the degree of enrichment, from red (very significantly enriched) to white (not enriched). The results confirmed the enrichment of the GO terms that are related to the regulation of cell death and apoptotic processes, as well as to the regulation of glutamatergic synaptic transmission (a), response to stimulus, response to oxidative stress and reactive oxygen species, response to calcium ion (b), biological quality and synaptic plasticity (c). A detailed overview of GO enrichment analysis is presented in Additional file 1: Fig. S1 and Additional file 2: Table S1