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Fig. 5 | Biological Research

Fig. 5

From: Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats

Fig. 5

The knockdown efficiency of TGR5 siRNA. Representative Western blots (a), and TGR5 knockout worsened neurobehavioral deficits, exacerbated brain water content (b). Knockdown TGR5 abolished the anti-apoptotic effect of TUDCA after subarachnoid hemorrhage (SAH). c Representative Western blots and quantitative analyses of SIRT3, BCL-2, BAX and cleaved caspase-3. Quantified neurological scores and brain water content (d), n = 6 per group. *P < 0.05 vs sham, #P < 0.05 vs SAH + vehicle. Scr siRNA, scramble siRNA

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Biological Research

ISSN: 0717-6287

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