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Fig. 4 | Biological Research

Fig. 4

From: Knockdown of lncRNA TUG1 inhibits hippocampal neuronal apoptosis and participates in aerobic exercise-alleviated vascular cognitive impairment

Fig. 4

Aerobic exercise alleviates mouse VCI via downregulating TUG1. The mice were divided into five groups (n = 6 in each group), the sham group, the 2VO group (VCI mouse model was established by ligating bilateral CCAs), the 2VO + EX group (VCI mice underwent aerobic exercise for 4 weeks), the 2VO + EX + Lenti-control group (Lenti-control were injected into the ventricle of VCI mice, followed by the aerobic exercise for 4 weeks) and the 2VO + EX + Lenti-TUG1 group (Lenti-TUG1 were injected into the ventricle of VCI mice, followed by the aerobic exercise for 4 weeks). a Mouse brain tissues were collected and were stained by H&E. b The Morris water maze test was used to detect the latency for mice to reach the platform. c The TUG1 level in hippocampal tissues was detected by qRT-PCR. d The BDNF mRNA level was detected by qRT-PCR. e, f The protein expressions of BDNF, cleaved-Caspase 3, and Bcl-2 were detected by western blotting. g, h Cell apoptosis was detected by flow cytometry. *P < 0.05 vs. the sham group; **P < 0.05 vs. the 2VO group; #P < 0.05 vs. the 2VO + EX + Lenti-control group

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