Table 1 Cell cycle gene expression by real-time PCR array in lung homogenate of mice at 4- and 12-weeks of age exposed to 30Â min of 40%O2 within 6Â h of birth
From: Short-term perinatal oxygen exposure may impair lung development in adult mice
Gene symbol | Gene description | Fold change in gene expression |
|---|---|---|
40%O2 Group—4 weeks (Control Group—21%O2 4 weeks) | ||
Over-expressed genes | ||
 Cdk4 | Cyclin-dependent kinase 4 | 4.26 (0.01–16.5) |
 Dst | Dystonin | 4.34 (0.01–15.4) |
 Msh2 | MutS homolog 2 (E. coli) | 2.64 (0.01–9.35) |
 Psmg2 | Proteasome assembly chaperone 2 | 3.28 (0.01–10.3) |
 Rbl1 | Retinoblastoma-like protein 1 | 2.56 (0.01–7.06) |
 Shc1 | Src homology 2 transforming protein C1 | 2.21 (0.01–5.09) |
 Trp63 | Transformation related protein p63 | 2.37 (0.01–5.67) |
Under-Expressed Genes | ||
 Ccnb1 | Cyclin B1 | 0.36 (0.01–1.04) |
 Ccnb2 | Cyclin B2 | 0.50 (0.19–0.82) |
 Gpr132 | G protein-coupled receptor 132 | 0.15 (0.01–0.76) |
 Mcm3 | Minichromosome maintenance complex-3 | 0.17 (0.01–0.70) |
40%O2 Group—12 weeks (Control Group—21%O2 12 weeks) | ||
Over-expressed genes | ||
 Ccnb1 | Cyclin B1 | 5.9 (0.01–10.75) |
 Trp63 | Transformation related protein p63 | 4.16 (0.01–11.59) |
Under-expressed genes | ||
 Abl1 | Non-receptor tyrosine protein kinase | 0.28 (0.01–0.67) |